Evidence map›Paper›PMID 35914833›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial Infection.

Ellyse M Cipolla, Molin Yue, Kara L Nickolich, Brydie R Huckestein, Danielle Antos, Wei Chen, John F Alcorn

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. IFNγ-induction of TNature immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ellyse M CipollaDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.ORCID 0000-0001-7637-228X
Molin YueDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-3339-892X
Kara L NickolichDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.ORCID 0000-0001-8817-6892
Brydie R HuckesteinDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.ORCID 0000-0002-0110-6793
Danielle AntosDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.
Wei ChenDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.ORCID 0000-0001-7196-8703
John F AlcornDepartment of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA; john.alcorn@chp.edu.

Funding

Influenza A Inhibits TH17 Host Defense Against Bacterial PneumoniaR01HL107380 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALCORN, JOHN F · 2012 to 2024
$5.4M
Multi-omics Analysis of Childhood Asthma in HispanicsR21HL150431 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS, CHEN, WEI · 2020 to 2021
$235k
NHLBI NIH HHS R01 HL107380NHLBI NIH HHS R21 HL150431
6 · The paper itself

Abstract

Influenza-associated bacterial superinfections have devastating impacts on the lung and can result in increased risk of mortality. New strains of influenza circulate throughout the population yearly, promoting the establishment of immune memory. Nearly all individuals have some degree of influenza memory before adulthood. Due to this, we sought to understand the role of immune memory during bacterial superinfections. An influenza heterotypic immunity model was established using influenza A/Puerto Rico/8/34 and influenza A/X31. We report in this article that influenza-experienced mice are more resistant to secondary bacterial infection with methicillin-resistant

Indexed as

Bacterial InfectionsCoinfectionInfluenza, HumanMethicillin-Resistant Staphylococcus aureusOrthomyxoviridae InfectionsSuperinfectionAdultAnimalsCD8-Positive T-LymphocytesHumansLungMiceMice, Inbred C57BL

Identifiers

PMID35914833
PMCPMC9378502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.