ArticleLife science alliance2022
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In one paragraph
Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Regulation of mitochondrial fission by Drp1 in cardiomyopathy: possible mechanisms linking cellular processes to cell death.Molecular biology reports · 2026Review
- Reversibility and therapeutic feasibility of DNM1L-associated neurodevelopmental disorders.Experimental & molecular medicine · 2026Article
- Therapeutic potential of TMSC-Exo for non-alcoholic fatty liver disease using the liver-on-a-chip model.Journal of translational internal medicine · 2026Article
- Functional identification of two variants in unrelated Chinese patients with DNM1L-related mitochondrial disorders.BMC pediatrics · 2025Article
- Cardiac dysfunction due to mitochondrial impairment assessed by human iPS cells caused by DNM1L mutations.Pediatric research · 2025Article
- A De NovoBiomolecules · 2025Article
- Drp1 Proteins Released from Hydrolysis-Driven Scaffold Disassembly Trigger Nucleotide-Dependent Membrane Remodeling to Promote Scission.Journal of the American Chemical Society · 2025Article
- The Structure of the Drp1 Lattice on Membrane.Journal of molecular biology · 2025Article
- De NovoInternational journal of molecular sciences · 2025Review
- Clinical and genetic characterization ofFrontiers in pediatrics · 2025Article
- Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.Nature communications · 2024Article
- A novel variant of DNM1L expanding the clinical phenotypic spectrum: a case report and literature review.BMC pediatrics · 2024Review
- Altered Mitochondrial Function and Accelerated Aging Phenotype in Neural Stem Cells Derived from Dnm1l Knockout Embryonic Stem Cells.International journal of molecular sciences · 2023Article
- Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery.Human molecular genetics · 2023Article
- DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs.Journal of cell science · 2023Article
- Broadening horizons: the contribution of mitochondria-associated endoplasmic reticulum membrane (MAM) dysfunction in diabetic kidney disease.International journal of biological sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 16 institutions in 5 countries.
Kelsey A NoldenDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0003-2235-7900
John M EgnerDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.
Jack J CollierWellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.
Oliver M RussellWellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.
Charlotte L AlstonWellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.
Megan C HarwigDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.
Michael E WidlanskyDepartment of Medicine, Division of Cardiovascular Medicine and Department of Pharmacology, Medical College of Wisconsin, Milwaukee, WI, USA.
Souphatta SasorithLaboratoire de Génétique Moléculaire, Centre Hospitalier Universitaire and PhyMedExp, INSERM U1046, CNRS UMR 9214, Montpellier, France.ORCID 0000-0001-8448-1726
Inês A BarbosaDepartment of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King's College London, London, UK.ORCID 0000-0001-8740-4523
Andrew Gl DouglasWessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Southampton, UK.ORCID 0000-0001-5154-6714
Julia BaptistaPeninsula Medical School, Faculty of Health, University of Plymouth, Plymouth, UK.ORCID 0000-0003-0915-5028
Mark WalkerDepartment of Cellular Pathology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Deirdre E DonnellyNorthern Ireland Regional Genetics Centre, Belfast Health and Social Care Trust, Belfast City Hospital, Belfast, UK.
Andrew A MorrisWillink Metabolic Unit, Manchester Centre for Genomic Medicine, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.ORCID 0000-0002-7854-4396
Hui Jeen TanDepartment of Paediatric Neurology, Royal Manchester Children's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Manju A KurianDevelopmental Neurosciences Department, Zayed Centre for Research into Rare Diseases in Children, University College London Great Ormond Street Institute of Child Health, Faculty of Population Health Sciences, London, UK.
Kathleen GormanDepartment of Neurology and Clinical Neurophysiology, Children's Health Ireland at Temple Street, Dublin, Ireland.
Santosh MordekarDepartment of Paediatric Neurology, Sheffield Children's Hospital, Sheffield, UK.ORCID 0000-0002-6135-1969
Charu DeshpandeClinical Genetics Unit, Guys and St. Thomas' NHS Foundation Trust, London, UK.
Rajib SamantaDepartment of Paediatric Neurology, University Hospitals Leicester NHS Trust, Leicester, UK.
Robert McFarlandWellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.
R Blake HillDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID 0000-0001-6228-3905
Robert W TaylorWellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.ORCID 0000-0002-7768-8873
Monika OláhováWellcome Centre for Mitochondrial Research, Newcastle University, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK monika.olahova@ncl.ac.uk.ORCID 0000-0002-4082-3875
Medical College of Wisconsin · USNational Health Service · GBUniversity Hospital Southampton NHS Foundation Trust · GBWellcome Centre for Mitochondrial Research · GBBelfast Health and Social Care Trust · GBCentre National de la Recherche Scientifique · FRGuy's and St Thomas' NHS Foundation Trust · GBKing's College London · GBMontreal Neurological Institute and Hospital · CARoyal Manchester Children's Hospital · GBSheffield Children's Hospital · GBUniversity College Dublin · IEUniversity College London · GBUniversity Hospitals of Leicester NHS Trust · GBUniversity of Manchester · GBUniversity of Plymouth · GB
Funding
Structural Biology of Mitochondrial FissionR01GM067180 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI HILL, R BLAKE · 2004 to 2022
$6.0MMedical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7MJ. NRSA Training CoreTL1TR001437 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI THOMAS, DANNY GEORGE · 2015 to 2024
$3.7MEndothelial function in human diabetes: role of mitochondrial fission proteinsR01HL128240 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2016 to 2020
$2.9MAn Automated Microscale Thermophoresis Instrument for Southeastern Wisconsin: a Shared Resource for Biomolecular Interactions and Drug DiscoveryS10OD025036 · OD · MEDICAL COLLEGE OF WISCONSIN · PI HILL, R BLAKE · 2019 to 2019
$582kMedical Research Council G0800674Medical Research Council MR/S005021/1NCATS NIH HHS TL1 TR001437NHLBI NIH HHS R01 HL128240NIGMS NIH HHS R01 GM067180NIGMS NIH HHS T32 GM080202NIH HHS S10 OD025036Wellcome TrustWellcome Trust 203105/Z/16/Z
Abstract
Imbalances in mitochondrial and peroxisomal dynamics are associated with a spectrum of human neurological disorders. Mitochondrial and peroxisomal fission both involve dynamin-related protein 1 (DRP1) oligomerisation and membrane constriction, although the precise biophysical mechanisms by which distinct DRP1 variants affect the assembly and activity of different DRP1 domains remains largely unexplored. We analysed four unreported de novo heterozygous variants in the dynamin-1-like gene
Indexed as
Mitochondrial DynamicsMitochondrial ProteinsDynaminsGTP PhosphohydrolasesHumansMicrotubule-Associated ProteinsMitochondriaDNM1L protein, humanDynaminsGTP PhosphohydrolasesMicrotubule-Associated ProteinsMitochondrial Proteins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.