Evidence map›Paper›PMID 35914768›Full record

ReviewAnnual review of pharmacology and toxicology2023

Pharmacogenetics of Antiplatelet Therapy.

Matteo Castrichini, Jasmine A Luzum, Naveen Pereira

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of pharmacology and toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Challenges and prospects ofFrontiers in pharmacology · 2026
    Review
  9. Distribution ofFrontiers in genetics · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Association ofBalkan journal of medical genetics : BJMG · 2024
    Article
  16. Circulation · 2024
    Review
  17. From genes to drugs:Frontiers in pharmacology · 2024
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Matteo CastrichiniDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; email: pereira.naveen@mayo.edu.
Jasmine A LuzumDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.
Naveen PereiraDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA; email: pereira.naveen@mayo.edu.
Mayo Clinic · USUniversity of Michigan–Ann Arbor · US

Funding

Precision Medicine for Heart Failure: The Role of Genomics in the Efficacy and Racial Disparity of Cornerstone PharmacotherapyK08HL146990 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUZUM, JASMINE A · 2019 to 2023
$772k
NHLBI NIH HHS K08 HL146990
6 · The paper itself

Abstract

Antiplatelet therapy is used in the treatment of patients with acute coronary syndromes, stroke, and those undergoing percutaneous coronary intervention. Clopidogrel is the most widely used antiplatelet P2Y12 inhibitor in clinical practice. Genetic variation in

Indexed as

PharmacogeneticsPlatelet Aggregation InhibitorsClopidogrelCytochrome P-450 CYP2C19GenotypeHumansProspective StudiesReproducibility of ResultsTreatment OutcomeClopidogrelCytochrome P-450 CYP2C19Platelet Aggregation InhibitorsCYP2C19dual antiplatelet therapyguided antiplatelet therapypharmacogeneticspharmacogenomicsprecision medicine

Identifiers

PMID35914768
PMCPMC9868113
OpenAlexW4289313488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.