Evidence map›Paper›PMID 35914582›Full record

ReviewSurvey of ophthalmology

Role of inflammatory cells in pathophysiology and management of diabetic retinopathy.

Elias Kovoor, Sunil K Chauhan, Amir Hajrasouliha

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  11. Acrolein Promotes Retinal Inflammation Through Macrophage Chemotaxis by Inducing CCL2 Production From Müller Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Elias KovoorCarver College of Medicine, University of Iowa, Iowa City, IA, USA.
Sunil K ChauhanSchepens Eye Institute, Harvard Medical School, Boston, MA, USA.
Amir HajrasoulihaDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: amhajras@iu.edu.
Indiana University School of MedicineMassachusetts Eye and Ear Infirmary · USUniversity of Iowa · US

Funding

Contribution of Mast Cells in Non-Allergic Ocular InflammationR01EY029727 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Sunil K Chauhan · 2019 to 2026
$4.2M
NEI NIH HHS R01 EY029727
6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a sight-threatening complication of diabetes mellitus. Several inflammatory cells and proteins, including macrophages and microglia, cytokines, and vascular endothelial growth factors, are found to play a significant role in the development and progression of DR. Inflammatory cells play a significant role in the earliest changes seen in DR including the breakdown of the blood retinal barrier leading to leakage of blood into the retina. They also have an important role in the pathogenesis of more advanced stage of proliferative diabetic retinopathy, leading to neovascularization, vitreous hemorrhage, and tractional retinal detachment. In this review, we examine the function of numerous inflammatory cells involved in the pathogenesis, progression, and role as a potential therapeutic target in DR. Additionally, we explore the role of inflammation following treatment of DR.

Indexed as

Diabetes MellitusDiabetic RetinopathyCytokinesHumansRetinaVascular Endothelial Growth FactorsVitreous HemorrhageCytokinesVascular Endothelial Growth FactorsDiabetic retinopathyimmune cellsinflammationintravitreal injectionvascular proliferation

Identifiers

PMID35914582
PMCPMC11082823
OpenAlexW4288737819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.