Evidence map›Paper›PMID 35914520›Full record

ArticleThe Journal of clinical endocrinology and metabolism2022

Comparison of Hormonal Response to a Mixed-Meal Challenge in Hypoglycemia After Sleeve Gastrectomy vs Gastric Bypass.

Clare J Lee, Jeanne M Clark, Josephine M Egan, Olga D Carlson, Michael Schweitzer, Susan Langan, Todd Brown

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07747779 (Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid Obesity), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07747779 narecruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Hormonal Response to a Mixed-Meal Tolerance Test After Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Sleeve Gastrectomy With Duodenojejunal Bypass in Patients With Super Morbid Obesity: A Prospective Single-Center Non-Inferiority Randomized Clinical Trial

TypeinterventionalSponsorChulalongkorn UniversityRan2024 to 2027Enrolled32ConditionsBariatric Surgery, Hormonal Response, Post Bariatric HypoglycemiaArmsSleeve gastrectomy with duodenojejunal bypass, Roux-en-Y gastric bypass
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Clare J LeeDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA.ORCID 0000-0002-0824-0207
Jeanne M ClarkDivision of General Internal Medicine, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA.
Josephine M EganNational Institute On Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Olga D CarlsonNational Institute On Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Michael SchweitzerDepartment of Surgery, The Johns Hopkins University, Baltimore, Maryland 21287, USA.
Susan LanganDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA.
Todd BrownDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA.
Johns Hopkins University · USNational Institutes of Health · US

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Mentoring in Endocrine and Metabolic Abnormalities in HIV and AgingK24AI120834 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T · 2015 to 2025
$1.8M
Exploring Mechanisms of Changes in Glucose Homeostasis After Bariatric Surgery: Comparing Vertical Sleeve Gastrectomy and Roux-en-Y Gastric BypassK23DK107921 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LEE, CLARE JUNG EUN · 2016 to 2018
$582k
NCATS NIH HHS UL1 TR003098NIAID NIH HHS K24 AI120834NIDDK NIH HHS K23 DK107921
6 · The paper itself

Abstract

contextExaggerated postprandial incretin and insulin responses are well documented in postbariatric surgery hypoglycemia (PBH) after Roux-en-Y gastric bypass (RYGB). However, less is known about PBH after sleeve gastrectomy (SG).

objectiveWe sought to compare meal-stimulated hormonal response in those with PBH after SG vs RYGB.

methodsWe enrolled 23 post-SG (12 with and 11 without PBH) and 20 post-RYGB (7 with and 13 without PBH) individuals who underwent bariatric surgery at our institution. PBH was defined as plasma glucose less than 60 mg/dL on 4-hour mixed-meal tolerance test (MTT). Islet and incretin hormones were compared across the 4 groups.

resultsParticipants (N = 43) were on average 5 years post surgery, with a mean age of 48 years, mean preoperative body mass index of 48.4, 81% female, 61% White, and 53% post SG. Regardless of PBH, the SG group showed lower glucose, glucagon, and glucagon-like peptide 1 (GLP-1) responses to MTT and similar insulin and glucose-dependent insulinotropic polypeptide (GIP) responses compared to the RYGB group. Among those with PBH, the SG group following the MTT showed a lower peak glucose (P = .02), a similar peak insulin (90.3 mU/L vs 171mU/L; P = .18), lower glucagon (P < .01), early GLP-1 response (AUC0-60 min; P = .01), and slower time to peak GIP (P = .02) compared to PBH after RYGB.

conclusionAmong individuals with PBH, those who underwent SG were significantly different compared to RYGB in meal-stimulated hormonal responses, including lower glucagon and GLP-1 responses, but similar insulin and GIP responses. Future studies are needed to better understand the differential contribution of insulin and non-insulin-mediated mechanisms behind PBH after SG vs RYGB.

Indexed as

Gastric BypassHypoglycemiaObesity, MorbidBlood GlucoseFemaleGastrectomyGastric Inhibitory PolypeptideGlucagonGlucagon-Like Peptide 1GlucoseHumansIncretinsInsulinMaleMiddle AgedBlood GlucoseGastric Inhibitory PolypeptideGlucagonGlucagon-Like Peptide 1GlucoseIncretinsInsulingastric bypassGIPGLP-1hypoglycemiaRYGBsleeve gastrectomy

Identifiers

PMID35914520
PMCPMC9516126
OpenAlexW4289295560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.