ArticleProceedings of the National Academy of Sciences of the United States of America2022
Selective engram coreactivation in idling brain inspires implicit learning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Offline generative network reconfiguration guides insight-like accelerated learning by assimilation into schema in rats.Nature communications · 2026Article
- The prefrontal cortex controls memory organization in the hippocampus.Nature neuroscience · 2026Article
- Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025.Molecular brain · 2026Review
- The Emergence of New Schema Memory Requires Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Sleep transcends limited knowledge to support logical reward-related decisions in a novel task in male mice.Molecular brain · 2025Article
- Offline consolidation mechanisms of the retrieval practice effect: an analysis based on EEG signal characteristics.NPJ science of learning · 2025Article
- The medial prefrontal cortex encodes procedural rules as sequential neuronal activity dynamics.Molecular brain · 2025Article
- Article
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration.Molecular brain · 2025Article
- Multi-region processing during sleep for memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Article
- Sleep and quiet wakefulness signify an idling brain hub for creative insights.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Prefrontal coding of learned and inferred knowledge during REM and NREM sleep.Nature communications · 2024Article
- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning.Biology open · 2022Article
- A short-term memory trace persists for days in the mouse hippocampus.Communications biology · 2022Article
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Authors and funding
5 authors.
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Abstract
Passive priming of prior knowledge to assimilate ongoing experiences underlies advanced cognitive processing. However, the necessary neural dynamics of memory assimilation remains elusive. Uninstructed brain could also show boosted creativity, particularly after idling states, yet it remains unclear whether the idling brain can spontaneously spark relevant knowledge assimilations. We established a paradigm that links/separates context-dependent memories according to geometrical similarities. Mice exploring one of four contexts 1 d before undergoing contextual fear conditioning in a square context showed a gradual fear transfer to preexposed geometrically relevant contexts the next day, but not after 15 min. Anterior cingulate cortex neurons representing relevant, rather than distinct, memories were significantly coreactivated during postconditioning sleep only, before their selective integration the next day during testing. Disrupting sleep coreactivations prevented assimilation while preserving recent memory consolidation. Thus, assimilating pertinent memories during sleep through coreactivation of their respective engrams represents the neural underpinnings of sleep-triggered implicit cortical learning.
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