ArticleEnvironmental health perspectives2022
Estimating National Exposures and Potential Bladder Cancer Cases Associated with Chlorination DBPs in U.S. Drinking Water.
Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Trihalomethane Concentrations Measured at the Tap are a Poor Predictor of Haloacetonitrile Concentrations in Small Rural Drinking Water Systems.Environment & health (Washington, D.C.) · 2026Article
- Detection of microplastics in bladder wash fluid obtained after cystoscopy in patients diagnosed with bladder cancer.Frontiers in public health · 2026Observational
- Malignant Transformation of Human Uroepithelial Cells Induced by Long-Term Exposure to a Disinfection Byproduct2,6-Dichlorobenzoquinone.Environment & health (Washington, D.C.) · 2025Article
- Disinfection Byproducts Confirmed over 50 Years: Systematic Curation, Modes of Toxic Action, and Toxicogenomics.Environmental science & technology · 2025Review
- Multipathway health risk assessment on disinfection byproducts of drinking water in central China: a study of 15,280 samples.Journal of water and health · 2025Article
- Moving Beyond the Silos of Opportunistic Pathogen and Disinfection Byproduct Research to Improve Drinking Water System Management.Environmental science & technology · 2025Review
- Haloacetonitriles Induce Structure-Related Cellular Toxicity Through Distinct Proteome Thiol Reaction Mechanisms.ACS environmental Au · 2025Article
- Low daily water intake profile-is it a contributor to disease?Nutrition and health · 2024Review
- Risk Factors Associated with Urothelial Bladder Cancer.International journal of environmental research and public health · 2024Review
- Evaluation of distribution system water quality during a free chlorine conversion.AWWA water science · 2024Article
- Association of Domestic Water Hardness with All-Cause and Cause-Specific Cancers: Evidence from 447,996 UK Biobank Participants.Environmental health perspectives · 2024Article
- Cytotoxicity Comparison between Drinking Water Treated by Chlorination with Postchloramination versus Granular Activated Carbon (GAC) with Postchlorination.Environmental science & technology · 2023Article
- Global assessment of chemical quality of drinking water: The case of trihalomethanes.Water research · 2023Article
- Pomegranate (Foods (Basel, Switzerland) · 2022Article
- Invited Perspective: Existing Rules for Disinfection By-Products Are Good, but They Are Not Enough.Environmental health perspectives · 2022Article
- Bladder Cancer in Lebanon: An Updated Epidemiological Comparison with Global Regions and a Comprehensive Review of Risk Factors.Cancer control : journal of the Moffitt Cancer CenterReview
- Urinary mutagenicity and bladder cancer risk in northern New England.Environmental and molecular mutagenesisArticle
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisinfection byproducts (DBPs) in public water systems (PWS) are an unintended consequence resulting from reactions between mostly chlorine-based disinfectants and organic and inorganic compounds in source waters. Epidemiology studies have shown that exposure to DBP (specifically trihalomethanes) was associated with an increased risk of bladder cancer.
objectiveOur goal was to characterize the relative differences in exposures and estimated potential bladder cancer risks for people served by different strata of PWS in the United States and to evaluate uncertainties associated with these estimates.
methodsWe stratified PWS by source water type (surface vs. groundwater) and population served (large, medium, and small) and calculated population-weighted mean trihalomethane-4 (THM4) concentrations for each stratum. For each stratum, we calculated a population attributable risk (PAR) for bladder cancer using odds ratios derived from published pooled epidemiology estimates as a function of the mean THM4 concentration and the fraction of the total U.S. population served by each stratum of systems. We then applied the stratum-specific PARs to the total annual number of new bladder cancer cases in the U.S. population to estimate bladder cancer incidence in each stratum.
resultsOur results show that approximately 8,000 of the 79,000 annual bladder cancer cases in the United States were potentially attributable to DBPs in drinking water systems. The estimated attributable cases vary based on source water type and system size. Approximately 74% of the estimated attributable cases were from surface water systems serving populations of DISCUSSION: Despite significant reductions in exposure over the past several decades, our study suggests that
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