Evidence map›Paper›PMID 35913760›Full record

ArticlePhysical therapy2022

Effects of Neural Mobilization on Sensory Dysfunction and Peripheral Nerve Degeneration in Rats With Painful Diabetic Neuropathy.

Guan-Cheng Zhu, Yu-Wen Chen, Kun-Ling Tsai, Jhi-Joung Wang, Ching-Hsia Hung, Annina B Schmid

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physical therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Guan-Cheng ZhuDepartment of Physical Therapy, National Cheng Kung University, Tainan, Taiwan (R.O.C.).ORCID 0000-0002-2690-3510
Yu-Wen ChenDepartment of Physical Therapy, China Medical University, Taichung, Taiwan (R.O.C.).
Kun-Ling TsaiDepartment of Physical Therapy, National Cheng Kung University, Tainan, Taiwan (R.O.C.).
Jhi-Joung WangDepartment of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan (R.O.C.).
Ching-Hsia HungDepartment of Physical Therapy, National Cheng Kung University, Tainan, Taiwan (R.O.C.).ORCID 0000-0001-6316-4342
Annina B SchmidNuffield Department of Clinical Neuroscience, University of Oxford, John Radcliffe Hospital, Oxford, UK.
National Cheng Kung University · TWChi Mei Medical Center · TWChina Medical University · TWJohn Radcliffe Hospital · GB

Funding

Wellcome Trust 222101Wellcome Trust 222101/Z/20/Z
6 · The paper itself

Abstract

objectiveThis study aims to evaluate the effectiveness of neural mobilization (NM) in the management of sensory dysfunction and nerve degeneration related to experimental painful diabetic neuropathy (PDN).

methodsThis is a pre-clinical animal study performed in the streptozocin-induced diabetic rat model. Three groups were included: a treatment group of rats with PDN receiving NM under anesthesia (PDN-NM, n = 10), a sham treatment group of rats with PDN that received only anesthesia (PDN-Sham, n = 9), and a vehicle control group with nondiabetic animals (Vehicle, n = 10). Rats in the PDN-NM and PDN-Sham groups received 1 treatment session on days 10, 12, and 14 after streptozocin injection, with a 48-hour rest period between sessions. Behavioral tests were performed using von Frey and Plantar tests. Evaluation for peripheral nerve degeneration was performed through measuring protein gene product 9.5-positive intra-epidermal nerve fiber density in hind-paw skin biopsies. All measurements were performed by a blinded investigator.

resultsThe behavioral tests showed that a single NM session could reduce hyperalgesia, which was maintained for 48 hours. The second treatment session further improved this treatment effect, and the third session maintained it. These results suggest that it requires multiple treatment sessions to produce and maintain hypoalgesic effects. Skin biopsy analysis showed that the protein gene product 9.5-positive intra-epidermal nerve fiber density was higher on the experimental side of the PDN-NM group compared with the PDN-Sham group, suggesting NM may mitigate the degeneration of peripheral nerves.

conclusionThis study demonstrated that NM may be an effective method to manage experimentally induced PDN, potentially through mitigation of nerve degeneration. Further studies are needed to develop standardized protocols for clinical use. IMPACT: These findings provide neurophysiological evidence for the use of NM in PDN and can form the basis for the development of physical therapy-based programs in clinics.

Indexed as

Diabetes MellitusDiabetic NeuropathiesAnimalsNerve DegenerationPeripheral NervesRatsStreptozocinStreptozocinDiabetic NeuropathiesNerve DegenerationPain Management

Identifiers

PMID35913760
PMCPMC7613682
OpenAlexW4289336398

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.