ArticlePeriodontology 20002022
Concise evaluation and therapeutic guidelines for severe periodontitis: A public health perspective.
Article in Periodontology 2000, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Differential Associations of Human Herpesviruses With Oral Bacteria and Periodontitis Severity: A Cross-Sectional Analysis.International dental journal · 2026Article
- Turmeric-derived nanovesicles reprogram pathological NETosis to mitigate inflammatory bone loss.Journal of nanobiotechnology · 2026Article
- Article
- Impact of emerging and re-emerging viral infections on periodontitis progression.Archives of microbiology · 2025Review
- Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- In Situ Valence Engineering of Copper Silicate Nanozymes with Enhanced Peroxidase-Like Catalytic Activity for Oral Disease Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The relationship between maternal periodontitis and congenital cytomegalovirus: A hypothetical model and therapeutic implications.Periodontology 2000 · 2025Review
- TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2.Inflammation · 2024Article
- Severe periodontitis and congenital cytomegalovirus: Cleft lip and cleft palate.Periodontology 2000 · 2024Review
- Elevated subgingival temperature infers high bacterial pathogen counts in severe periodontitis.Clinical and experimental dental research · 2024Article
- Antimicrobial Chemotherapy for Recalcitrant Severe Human Periodontitis.Antibiotics (Basel, Switzerland) · 2023Article
- Bee Sting-Inspired Inflammation-Responsive Microneedles for Periodontal Disease Treatment.Research (Washington, D.C.) · 2023Article
- Concise evaluation and therapeutic guidelines for severe periodontitis: A public health perspective.Periodontology 2000 · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main goal of periodontology is to prevent and arrest gingivitis and periodontitis to avoid tooth loss and focal infection of periodontal origin. Periodontal scaling or flap surgery of moderate-to-severe periodontitis have shortcomings, most likely because removal of herpesviruses and bacterial pathogens in deep periodontal lesions and the adjacent inflamed gingiva requires systemic antimicrobial treatment (or gingivectomy). Valacyclovir (1000 mg twice daily on day 1, and 500 mg twice daily on day 2 and on day 3) is a potent anti-herpesvirus agent. Antibiotic combinations against bacterial pathogens include amoxicillin-metronidazole (250 mg of each, thrice daily for 4 days; for systemically healthy adults) and ciprofloxacin-metronidazole (500 mg of each, twice daily for 4 days; for immunosuppressed individuals and patients exposed to contaminated water and poor sanitation). Supportive antiseptic treatment may consist of 0.1%-0.2% sodium hypochlorite (regular household bleach) as cooling spray in ultrasonic scalers, flosser fluid in oral irrigators, and mouthrinse in patient self-care. The anti-infective treatment described here helps control cases of severe periodontitis and constitutes an exceedingly inexpensive alternative to conventional (mechanical) periodontal therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.