ArticlePain medicine (Malden, Mass.)2023
Pain, Opioid Analgesics, and Cognition: A Conceptual Framework in Older Adults.
Article in Pain medicine (Malden, Mass.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quality Indicators for the Pharmacological Management of Chronic Non-Cancer Pain in Older Adult Patients: An Integrative Review.Journal of evaluation in clinical practice · 2025Pooled it
- Anesthetic Techniques and Postoperative Cognitive Dysfunction in Older Adults: Current Evidence and Perioperative Strategies.Medicina (Kaunas, Lithuania) · 2026Review
- Impact of androgen receptor pathway inhibitors on cognitive function in older adults treated for metastatic prostate cancer.Communications medicine · 2025Article
- The impact of osteoarthritis and geriatric depression scale on mini-mental state examination trajectories over seven years.European journal of ageing · 2025Article
- High-impact pain predicts subjective cognitive decline and interacts with APOE4 genotype in the development of objective cognitive impairment.The journal of pain · 2025Article
- A Qualitative Study of the Effects of Opioids on Chronic Pain, Function, and Cognition in Community-Dwelling Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- Choosing well: A narrative review on chronic pain and decision-making.The journal of pain · 2025Review
- Understanding the first prescription: clinical and demographic drivers of strong opioid use in primary care.Pain medicine (Malden, Mass.) · 2025Article
- Drug-Induced Cognitive Impairment.Drug safety · 2025Review
- Observational evidence linking psychotropic medicines to the dispensing of opioid agents in later life.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2024Observational
- Risk Factors and Diagnostic Model Construction of Chronic Pain with Cognitive Impairment.Journal of pain research · 2024Article
- Pain Management for Older Adults Across the Cognitive Trajectory.Current geriatrics reports · 2023Article
- Prescription opioids and longitudinal changes in cognitive function in older adults: A population-based observational study.Journal of the American Geriatrics Society · 2022Observational
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Authors and funding
7 authors.
Funding
Abstract
Chronic pain is highly prevalent in older adults and is associated with poor functional outcomes. Furthermore, opioid analgesics are commonly utilized for the treatment of pain in older adults despite well-described adverse effects. Importantly, both chronic pain and opioid analgesics have been linked with impairments in cognitive function, though data are limited. In this manuscript we summarize the evidence and critical knowledge gaps regarding the relationships between pain, opioid analgesics, and cognition in older adults. Furthermore, we provide a conceptual framework to guide future research in the development, implementation, and evaluation of strategies to optimize analgesic outcomes in older adults while minimizing deleterious effects on cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.