Evidence map›Paper›PMID 35913405›Full record

ArticleACS applied bio materials2022

Platform for Active Vaccine Formulation Using a Two-Mode Enhancement Mechanism of Epitope Presentation by Pickering Emulsion.

Guy Mechrez, Karthik Ananth Mani, Abhijit Saha, Oded Lachman, Neta Luria, Ori Molad, Liliya Kotliarevski, Einat Zelinger, Elisheva Smith, Noga Yaakov and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Guy MechrezDepartment of Food Science, Institute of Postharvest and Food Science, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Karthik Ananth ManiDepartment of Food Science, Institute of Postharvest and Food Science, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Abhijit SahaInstitute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Oded LachmanDepartment of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Neta LuriaDepartment of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Ori MoladInstitute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Liliya KotliarevskiDepartment of Food Science, Institute of Postharvest and Food Science, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Einat ZelingerThe Interdepartmental Equipment Unit, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.
Elisheva SmithDepartment of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Noga YaakovDepartment of Food Science, Institute of Postharvest and Food Science, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Dalia Shabashov StonePharmaseed Ltd., Ness Ziona 74047, Israel.
Meital RechesInstitute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.ORCID 0000-0001-5652-9868
Aviv DombrovskyDepartment of Plant Pathology and Weed Research, Institute of Plant Protection, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel.
Agricultural Research Organization · ILHebrew University of Jerusalem · ILSRM Institute of Science and Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficiency of epitope-based vaccination (subunit vaccines) is tightly correlated with heterogeneity and the high density of epitope presentation, which maximizes the potential antigenic determinants. Here, we developed a two-mode platform for intensifying the epitope presentation of subunit vaccines. The two-mode epitope presentation enhancement includes a covalent attachment of high concentrations of SARS-CoV-2-S1 peptide epitope to the surface of virus-like-particles (VLPs) and the subsequent assembly of VLP/epitope conjugates on the oil droplet surface at an oil/water interface of an emulsion as Pickering stabilizers. The resultant emulsions were stable for weeks in ambient conditions, and our platform was challenged using the epitope of the SARS-CoV-2-S1 peptide that served as a model epitope in this study.

Indexed as

COVID-19SARS-CoV-2AnimalsEmulsionsEpitopesImmunoglobulin GMiceVaccinationVaccines, SubunitEmulsionsEpitopesImmunoglobulin GVaccines, Subunitepitope-based vaccinationPickering emulsionplant virussubunit vaccinesvirus-like-particles

Identifiers

PMID35913405
PMCPMC9382630
OpenAlexW4289339435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.