Evidence map›Paper›PMID 35913176›Full record

ArticleMicrobiology spectrum2022

Primary Murine Macrophages as a Tool for Virulence Factor Discovery in Coxiella burnetii.

Elizabeth Di Russo Case, Saugata Mahapatra, Caitlyn T Hoffpauir, Kranti Konganti, Andrew E Hillhouse, James E Samuel, Erin J Van Schaik

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Virulence · 2026
    Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Frontiers in immunology · 2025
    Article
  9. Article
  10. The multifunctionProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
  13. Caspase-8 activity mediates TNFα production and restrictsbioRxiv : the preprint server for biology · 2024
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elizabeth Di Russo CaseDepartment of Veterinary Sciences, University of Wyoming, Laramie, Wyoming, USA.ORCID 0000-0002-9129-3894
Saugata MahapatraDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, Texas, USA.
Caitlyn T HoffpauirDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, Texas, USA.
Kranti KongantiInstitute for Genome Sciences and Society, Texas A&M University, College Station, Texas, USA.
Andrew E HillhouseInstitute for Genome Sciences and Society, Texas A&M University, College Station, Texas, USA.
James E SamuelDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, Texas, USA.
Erin J Van SchaikDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, Texas, USA.
Texas A&M Health Science Center · USTexas A&M University · USUniversity of Wyoming · US

Funding

Identification and Role of Type IV Secretion Effector Proteins in Coxiella burnetiiR01AI090142 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SAMUEL, JAMES EVANS · 2012 to 2024
$3.4M
NIAID NIH HHS R01 AI090142
6 · The paper itself

Abstract

Coxiella burnetii requires a type IVB secretion system (T4SS) to promote intracellular replication and virulence. We hypothesized that

Indexed as

Coxiella burnetiiQ FeverAnimalsBacterial ProteinsHost-Pathogen InteractionsHumansMacrophagesMiceMice, SCIDVirulence FactorsBacterial ProteinsVirulence FactorsCoxiellainnate immunityphenotypic profilingprimary macrophagestype IVB secretion

Identifiers

PMID35913176
PMCPMC9430109
OpenAlexW4289315020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.