Evidence map›Paper›PMID 35913142›Full record

ArticlemSphere2022

Role of RpoS in Regulating Stationary Phase Salmonella Typhimurium Pathogenesis-Related Stress Responses under Physiological Low Fluid Shear Force Conditions.

Karla Franco Meléndez, Keith Crenshaw, Jennifer Barrila, Jiseon Yang, Sandhya Gangaraju, Richard R Davis, Rebecca J Forsyth, C Mark Ott, Rebin Kader, Roy Curtiss and 2 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Assessing transcriptomic responses ofMicrobiology spectrum · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Karla Franco Meléndez *Center for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
Keith Crenshaw *Center for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
Jennifer BarrilaCenter for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
Jiseon YangCenter for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
Sandhya GangarajuBiodesign Center for Fundamental and Applied Microbiomics, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
Richard R DavisCenter for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
Rebecca J ForsythCenter for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
C Mark OttBiomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, Texas, USA.
Rebin KaderCenter for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
Roy CurtissCenter for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
Kenneth RolandBiodesign Center for Fundamental and Applied Microbiomics, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.
Cheryl A NickersonCenter for Infectious Diseases and Vaccinology, the Biodesign Institute, Arizona State Universitygrid.215654.1, Tempe, Arizona, USA.ORCID 0000-0002-9804-9739
Arizona State University · USJohnson Space Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery that biomechanical forces regulate microbial virulence was established with the finding that physiological low fluid shear (LFS) forces altered gene expression, stress responses, and virulence of the enteric pathogen Salmonella enterica serovar Typhimurium during the log phase. These log phase LFS-induced phenotypes were independent of the master stress response regulator, RpoS (σ

Indexed as

Salmonella typhimuriumSigma FactorAcidsBacterial ProteinsHumansVirulenceAcidsBacterial ProteinsSigma Factoracid stressbile salt stressbiomechanical forcesfluid shearinfectionintestinal epitheliummechanobiologymechanotransductionoxidative stresspathogenesisrotating wall vesselRpoSSalmonellasigma factorstationary-phasestress responsesthermal stressσ38 (sigma 38)σS (sigma S)

Identifiers

PMID35913142
PMCPMC9429890
OpenAlexW4289317232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.