Evidence map›Paper›PMID 35913102›Full record

Observational studyJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2022

Lichen planus in Germany - epidemiology, treatment, and comorbidity. A retrospective claims data analysis.

Eva Schruf, Mona Hc Biermann, Josephine Jacob, Dennis Häckl, Maximilian Reinhardt, Michael Hertl, Johannes Wohlrab

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. History, clinical presentation, therapy, and patient reported outcomes of mucosal lichen planus: a cross-sectional study.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Comprehensive Insight into Lichen Planus Immunopathogenesis.International journal of molecular sciences · 2023
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 7 institutions in 3 countries.

Eva SchrufNovartis Pharma GmbH, Nürnberg, Germany.
Mona Hc BiermannNovartis Pharma GmbH, Nürnberg, Germany.
Josephine JacobInGef-Institute for Applied Health Research Berlin GmbH, Berlin, Germany.
Dennis HäcklWIG2 GmbH, Leipzig, Germany.
Maximilian ReinhardtNovartis Pharma AG, Basel, Switzerland.
Michael HertlDepartment of Dermatology and Allergology, Philipps-Universität, Marburg, Germany.
Johannes WohlrabUniversity Hospital and Polyclinic for Dermatology and Venerology, Martin Luther University, Halle (Saale), Germany.
Institute for Applied Economic Research · DELeipzig University · DEMartin Luther University Halle-Wittenberg · DENovartis (Germany) · DENovartis (Switzerland) · CHPhilipps University of Marburg · DEZero to Three · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesLichen planus (LP) is a chronic inflammatory skin disease and is a major burden for affected patients. However, data on this condition are scarce. This study aims to expand the knowledge on the epidemiology and treatment patterns of LP using German health claims data. PATIENTS AND

methodsThis retrospective observational study was based on the InGef research database. Prevalent and incident LP patients were identified in the years 2015 and 2018. Descriptive statistics were calculated for demographic characteristics, treatment patterns, and comorbidity.

resultsThe prevalence of LP was 95.9 and the incidence was 20.1 per 100,000 individuals in 2018, corresponding to 79,605 prevalent LP cases in Germany. The first LP diagnosis was generally documented by a dermatologist or a primary care physician. Three-quarters of the incident and half of the prevalent patients received topical therapy, mostly without further systemic therapy. Comorbidity in LP patients was consistent with previously known associations.

conclusionsAvailable treatment options remain limited, underscoring the unmet need for safe and efficacious systemic treatment modalities. Lichen planus is frequently accompanied by clinically relevant systemic comorbidity. Taken together, these observations may improve our understanding of the burden of this disease and increase diagnostic awareness among clinicians.

Indexed as

Lichen PlanusSkin DiseasesComorbidityData AnalysisGermanyHumansRetrospective Studies

Identifiers

PMID35913102
PMCPMC9546356
OpenAlexW4289313782

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.