ArticleConnective tissue research2023
The adaptive response of the mandibular condyle to increased load is disrupted by ADAMTS5 deficiency.
Sarah C Porto, Alexandra Rogers-DeCotes, Emmaline Schafer, Christine B Kern
Open access · greenAbstract read
In one paragraphArticle in Connective tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
4 authors at 2 institutions in 1 country.
Sarah C PortoDepartment of Health and Human Performance, College of Charleston, Charleston, SC, USA.
Alexandra Rogers-DeCotesDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Emmaline SchaferDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Christine B KernDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Medical University of South Carolina · USCollege of Charleston · US
Funding
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1MT-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3MProteoglycan Metabolism During Cardiac Valve Development and DiseaseR01HL160802 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KERN, CHRISTINE BRUINS · 2022 to 2025
$2.1MProteoglycan Regulation During Cardiac Valve Development and HomeostasisR01HL121382 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KERN, CHRISTINE BRUINS · 2014 to 2017
$1.5MThe Requirement of ADAMTS5-mediated Cleavage of Aggrecan in Temporomandibular Joint DevelopmentF30DE028180 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ROGERS, ALEXANDRA · 2018 to 2021
$199kNCATS NIH HHS UL1 TR001450NHLBI NIH HHS R01 HL121382NHLBI NIH HHS R01 HL160802NIDCR NIH HHS F30 DE028180NIDCR NIH HHS T32 DE017551
6 · The paper itselfAbstract
objectiveTo determine the impact of increased load on the temporomandibular joint (TMJ) from mice deficient in the extracellular matrix protease ADAMTS5. MATERIALS AND
methodsWire springs exerting 0.5 N for 1 h/day for 5 days (Adamts5
resultsIncreased load on the mandibular condyle of
conclusionThe trabeculated bone of the
Indexed as
Mandibular CondyleMechanotransduction, CellularADAMTS5 ProteinAnimalsCartilageExtracellular MatrixMiceTemporomandibular JointADAMTS5 ProteinAdamts5 protein, mouseextracellular matrix, adamts5, mandibular condylematrix biologymatrix metalloproteinasestemporomandibular joint (tmj)
Identifiers
PMID35913086
PMCPMC9852085
OpenAlexW4289238836
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