Evidence map›Paper›PMID 35912999›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2022

A hydrogen-sulfide derivative of mesalamine reduces the severity of intestinal and lung injury in necrotizing enterocolitis through endothelial nitric oxide synthase.

Brian D Hosfield, Chelsea E Hunter, Hongge Li, Natalie A Drucker, Anthony R Pecoraro, Krishna Manohar, W Christopher Shelley, Troy A Markel

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Brian D HosfieldDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Chelsea E HunterDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Hongge LiDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Natalie A DruckerDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Anthony R PecoraroDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Krishna ManoharDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
W Christopher ShelleyDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
Troy A MarkelDepartment of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0002-6429-2976
Indiana University School of MedicineIndiana University Health · US

Funding

Mesenchymal Stromal Cells Modulate Intestinal Mesenteric Endothelium Via Hydrogen SulfideK08DK113226 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MARKEL, TROY A · 2018 to 2021
$603k
NIDDK NIH HHS K08 DK113226
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) remains a devastating disease that affects preterm infants. Hydrogen sulfide (H

Indexed as

Enterocolitis, NecrotizingHydrogen SulfideInfant, Newborn, DiseasesLung InjuryAnimalsAnimals, NewbornDisease Models, AnimalDisulfidesEosine Yellowish-(YS)HematoxylinHumansHydrogenInfant, NewbornInfant, PrematureInterleukin-6Intestinal Mucosa5-amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-(1,2)dithiol-3yl)phenyl esterDisulfidesEosine Yellowish-(YS)HematoxylinHydrogenHydrogen SulfideInterleukin-6MesalamineNitric OxideNitric Oxide Synthase Type IIISulfidesToll-Like Receptor 4endothelial nitric oxide synthasehydrogen sulfidenecrotizing enterocolitis

Identifiers

PMID35912999
PMCPMC9512109
OpenAlexW4289224118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.