Evidence map›Paper›PMID 35912993›Full record

ArticleAmerican journal of physiology. Cell physiology2022

Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron.

Brandi M Wynne, Trinity Kronk, Hayley C Moyer, Henrieke J van Elst, Auriel S Moseley, Gillian Hecht, Oishi Paul, Otor Al-Khalili, Celso Gomez-Sanchez, Benjamin Ko and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Targeting inerleukin-6 for renoprotection.Frontiers in immunology · 2024
    Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Brandi M WynneDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.ORCID 0000-0003-0861-4245
Trinity KronkDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.
Hayley C MoyerDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.
Henrieke J van ElstDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.
Auriel S MoseleyDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.
Gillian HechtDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.
Oishi PaulDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.
Otor Al-KhaliliDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.
Celso Gomez-SanchezG.V. (Sonny) Montgomery VA Medical Center, Jackson, Mississippi.
Benjamin KoDepartment of Medicine, Nephrology, University of Chicago, Chicago, Illinois.
Douglas C EatonDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.
Robert S HooverDepartment of Medicine, Nephrology, Emory University, Atlanta, Georgia.
Emory University · USRadboud University Nijmegen · NLTulane University · USUniversity of Chicago · USUniversity of Mississippi Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
STONE FORMATION IN GENETIC HYPERCALCIURIAP01DK056788 · NIDDK · UNIVERSITY OF CHICAGO · PI ASHKAR, TAREK MAURICE · 2000 to 2021
$22.5M
Nephrology Institutional Training Grant FLSA SupplementT32DK007656 · NIDDK · EMORY UNIVERSITY · PI SANDS, JEFF M, WALL, SUSAN MARIE · 1990 to 2020
$3.5M
Mechanisms of Hormonal Regulation of the Sodium Chloride CotransporterR01DK085097 · NIDDK · EMORY UNIVERSITY · PI HOOVER, ROBERT S · 2010 to 2015
$1.5M
Regulation of Sodium Transport in Tight EpitheliaR01DK110409 · NIDDK · EMORY UNIVERSITY · PI EATON, DOUGLAS C. · 2018 to 2021
$1.4M
Adrenal cell ATP1A1 mutations and mechanisms of aldosterone biosynthesisR01HL144847 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2019 to 2022
$1.3M
Aldosterone Independent Activation of the Mineralocorticoid Receptor via IL-6 and Rac1 Induces Sodium Retention and HypertensionK01DK115660 · NIDDK · UNIVERSITY OF UTAH · PI WYNNE, BRANDI MICHELE · 2018 to 2022
$1.0M
NCC and ENaC form a Sodium Transporting ComplexI01BX002322 · VA · VETERANS HEALTH ADMINISTRATION · PI HOOVER, ROBERT S · 2016 to 2020
–
Regulation of Mineralocorticoid Receptor ActionI01BX004681 · VA · G V SONNY MONTGOMERY VA MEDCIAL CENTER · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2021 to 2023
–
BLRD VA I01 BX002322BLRD VA I01 BX004681NHLBI NIH HHS R01 HL144847NIDDK NIH HHS K01 DK115660NIDDK NIH HHS P01 DK056788NIDDK NIH HHS R01 DK085097NIDDK NIH HHS R01 DK110409NIDDK NIH HHS T32 DK007656NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Hypertension is characterized by increased sodium (Na

Indexed as

AldosteroneReceptors, MineralocorticoidInterleukin-6Kidney Tubules, DistalNephronsReactive Oxygen SpeciesSodiumThiazidesAldosteroneInterleukin-6Reactive Oxygen SpeciesReceptors, MineralocorticoidSodiumThiazidescytokineepithelial transporthypertensionmineralocorticoid receptorsodium

Identifiers

PMID35912993
PMCPMC9662807
OpenAlexW4289344783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.