Evidence map›Paper›PMID 35912709›Full record

ArticleJournal of the American Heart Association2022

Clinical Correlates and Outcomes of Methamphetamine-Associated Cardiovascular Diseases in Hospitalized Patients in California.

Lara Curran, Gregory Nah, Gregory M Marcus, Zian Tseng, Michael H Crawford, Nisha I Parikh

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  9. Article
  10. Article
  11. A Mechanistic Review on Toxicity Effects of Methamphetamine.International journal of medical sciences · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Pulmonary Hypertension: A Contemporary Review.American journal of respiratory and critical care medicine · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lara CurranDepartment of Medicine Division of Cardiology, University of California San Francisco San Francisco CA.
Gregory NahDepartment of Medicine Division of Cardiology, University of California San Francisco San Francisco CA.ORCID 0000-0002-3543-519X
Gregory M MarcusDepartment of Medicine Division of Cardiology, University of California San Francisco San Francisco CA.ORCID 0000-0001-5197-7696
Zian TsengDepartment of Medicine Division of Cardiology, University of California San Francisco San Francisco CA.
Michael H CrawfordDepartment of Medicine Division of Cardiology, University of California San Francisco San Francisco CA.ORCID 0000-0001-7103-2278
Nisha I ParikhDepartment of Medicine Division of Cardiology, University of California San Francisco San Francisco CA.ORCID 0000-0002-4531-9897
University of California, San Francisco · US

Funding

Cardiac Pathology and Risk Prediction for Sudden Cardiac Death in Patients with HIVR01HL126555 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TSENG, ZIAN H · 2014 to 2017
$3.1M
NHLBI NIH HHS R01 HL126555
6 · The paper itself

Abstract

Background Methamphetamine misuse affects 27 million people worldwide and is associated with cardiovascular disease (CVD); however, risk factors for CVD among users have not been well studied. Methods and Results We studied hospitalized patients in California, captured by the Healthcare Cost and Utilization Project database, between 2005 and 2011. We studied the association between methamphetamine use and CVD (pulmonary hypertension, heart failure, stroke, and myocardial infarction). Among 20 249 026 persons in the Healthcare Cost and Utilization Project, 66 199 used methamphetamines (median follow-up 4.58 years). Those who used were more likely younger (33 years versus 45 years), male (63.3% versus 44.4%), smoked, misused alcohol, and had depression and anxiety compared with nonusers. Methamphetamine use was associated with the development of heart failure (hazard ratio [HR], 1.53 [95% CI, 1.45-1.62]) and pulmonary hypertension (HR, 1.42 [95% CI, 1.26-1.60]). Among users, male sex (HR, 1.73 [95% CI, 1.37-2.18]) was associated with myocardial infarction. Chronic kidney disease (HR, 2.38 [95% CI, 1.74-3.25]) and hypertension (HR, 2.26 [95% CI, 2.03-2.51]) were strong risk factors for CVD among users. When compared with nonuse, methamphetamine use was associated with a 32% significant increase in CVD, alcohol abuse with a 28% increase, and cocaine use with a 47% increase in CVD. Conclusions Methamphetamine use has a similar magnitude of risk of CVD compared with alcohol and cocaine. Prevention and treatment could be focused on those with chronic kidney disease, hypertension, and mental health disorders.

Indexed as

Cardiovascular DiseasesCocaineHeart FailureHypertensionHypertension, PulmonaryMethamphetamineMyocardial InfarctionRenal Insufficiency, ChronicHumansMaleRisk FactorsCocaineMethamphetaminecongestive heart failuremethamphetamineMINOCAmyocardial infarctionmyocardial infarction without coronary artery obstructionpulmonary hypertensionstroke

Identifiers

PMID35912709
PMCPMC9496303
OpenAlexW4289201887

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.