Evidence map›Paper›PMID 35912455›Full record

ArticleThe EMBO journal2022

The mystery of mitochondrial plasticity: TMBIM5 integrates metabolic state and proteostasis.

Mindong Ren, Michael Schlame

Open access · greenAbstract read
In one paragraph

Article in The EMBO journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mindong RenDepartments of Anesthesiology and Cell Biology, NYU School of Medicine, New York, NY, USA.
Michael SchlameDepartments of Anesthesiology and Cell Biology, NYU School of Medicine, New York, NY, USA.ORCID 0000-0003-0626-4026
New York University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How cellular cues alter the mitochondrial proteome and impact the composition of mitochondrial proteins remains poorly understood. In this issue of The EMBO Journal, Patron et al (2022) identify TMBIM5 as an important link between calcium homeostasis, proton motive force, and mitochondrial proteolysis, by which the organelle can modify its protein composition. The results may be crucial for our understanding of the plasticity of mitochondria.

Indexed as

MitochondriaProteostasisMitochondrial ProteinsProteolysisProteomeMitochondrial ProteinsProteome

Identifiers

PMID35912455
PMCPMC9379548
OpenAlexW4289339155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.