Evidence map›Paper›PMID 35912433›Full record

ArticleEpigenetics2022

Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort.

Saher Daredia, Karen Huen, Lars Van Der Laan, Philip A Collender, Jamaji C Nwanaji-Enwerem, Kim Harley, Julianna Deardorff, Brenda Eskenazi, Nina Holland, Andres Cardenas

Abstract read
In one paragraph

Article in Epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  18. Biomarkers of aging through the life course: A Recent Literature Update.Current opinion in epidemiology and public health · 2023
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saher DarediaDivision of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA, USA.ORCID 0000-0002-7906-4087
Karen HuenDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Lars Van Der LaanDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Philip A CollenderDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Jamaji C Nwanaji-EnweremDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Kim HarleyCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
Julianna DeardorffCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
Brenda EskenaziDivision of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA, USA.
Nina HollandDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Andres CardenasDivision of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, CA, USA.ORCID 0000-0003-2284-3298

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
Effect of early life exposure to social adversity and pesticides on risk-taking behavior of 16-18 year olds: the CHAMACOS studyR01ES026994 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2016 to 2020
$3.9M
DDT & PBDE exposure, puberty onset and neurodevelopment in Mexican-American girlsR01ES017054 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2009 to 2013
$3.2M
Molecular Mechanisms of Obesity in Children Exposed to Phthalates in UteroR01ES021369 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLLAND, NINA T · 2013 to 2017
$3.1M
Early Adversity Shapes Adolescent Risk Behavior Trajectories in Mexican Americans (Diversity Supplement)R01DA035300 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DEARDORFF, JULIANNA · 2014 to 2018
$3.1M
Common and Distinct Influences of Prenatal and Postnatal Early-Life Adversity on Epigenomic Trajectories in Mexican American ChildrenR01MD016595 · NIMHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI Andres Cardenas, Julianna Deardorff · 2022 to 2026
$3.0M
Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future GenerationsR24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Robert Gunier · 2017 to 2026
$2.0M
PRENATAL AND POSTNATAL EXPOSURE TO ENVIRONMENTAL MIXTURES: NEURODEVELOPMENT AND DNA METHYLATION BIOMARKERSR01ES031259 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CARDENAS, ANDRES · 2020 to 2024
$1.9M
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth CohortU24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GUNIER, ROBERT · 2023 to 2025
$1.1M
Early life influences on Epigenetic Aging in Mexican-American childrenR03AG067064 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLLAND, NINA T · 2020 to 2021
$159k
NIA NIH HHS R03 AG067064NIDA NIH HHS R01 DA035300NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R01 ES017054NIEHS NIH HHS R01 ES021369NIEHS NIH HHS R01 ES026994NIEHS NIH HHS R01 ES031259NIEHS NIH HHS R24 ES028529NIEHS NIH HHS U24 ES028529NIMHD NIH HHS R01 MD016595
6 · The paper itself

Abstract

Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood. We investigate the accuracy of GA clocks and determinants of epigenetic GA acceleration (GAA), a biomarker of biological ageing. We hypothesize that prenatal and birth characteristics are associated with altered GAA, thereby disrupting foetal biological ageing. We examined 372 mother-child pairs from the Center for the Health Assessment of Mothers and Children of Salinas study of primarily Latino farmworkers in California. Chronological GA was robustly correlated with epigenetic GA (DNAm GA) estimated by the Knight (

Indexed as

DNA MethylationEpigenesis, GeneticAccelerationEpigenomicsFemaleGestational AgeHumansInfantInfant, NewbornMalePregnancyVitaminsVitaminsage accelerationcord bloodDNA methylation ageepigenetic ageEpigenetic clocksgestational age

Identifiers

PMID35912433
PMCPMC9665122

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.