Evidence map›Paper›PMID 35912346›Full record

ArticleACS central science2022

Revealing a Hidden Intermediate of Rotatory Catalysis with X-ray Crystallography and Molecular Simulations.

Mrinal Shekhar, Chitrak Gupta, Kano Suzuki, Chun Kit Chan, Takeshi Murata, Abhishek Singharoy

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. NaNature structural & molecular biology · 2025
    Article
  6. Article
  7. Physical pictures of rotation mechanisms of FFrontiers in molecular biosciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Mrinal ShekharCenter for Development of Therapeutics, Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, Massachusetts 02142, United States.
Chitrak GuptaSchool of Molecular Sciences, Arizona State University, 797 East Tyler Street, Tempe, Arizona 85281, United States.
Kano SuzukiDepartment of Chemistry, Graduate School of Science, Chiba University, Inage-ku, Chiba, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan.
Chun Kit ChanSchool of Molecular Sciences, Arizona State University, 797 East Tyler Street, Tempe, Arizona 85281, United States.
Takeshi MurataDepartment of Chemistry, Graduate School of Science, Chiba University, Inage-ku, Chiba, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan.
Abhishek SingharoySchool of Molecular Sciences, Arizona State University, 797 East Tyler Street, Tempe, Arizona 85281, United States.ORCID https://orcid.org/0000-0002-9000-2397
Arizona State University · USBroad Institute · USChiba University · JPHigh Energy Accelerator Research Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanism of rotatory catalysis in ATP-hydrolyzing molecular motors remains an unresolved puzzle in biological energy transfer. Notwithstanding the wealth of available biochemical and structural information inferred from years of experiments, knowledge on how the coupling between the chemical and mechanical steps within motors enforces directional rotatory movements remains fragmentary. Even more contentious is to pinpoint the rate-limiting step of a multistep rotation process. Here, using vacuolar or V

Identifiers

PMID35912346
PMCPMC9336149
OpenAlexW4282840672

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.