ArticleFrontiers in oncology2022
Case Report: An Unusual Case of Pulmonary Metastatic Adenocarcinoma From Low-Grade Appendiceal Mucinous Neoplasms.
Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 5 citations in OpenAlex.
- Late Pulmonary and Lymph Node Recurrence 14 Years after Curative Resection of Incidentally Diagnosed Appendiceal Adenocarcinoma with Hepatic Metastasis.Surgical case reports · 2026Article
- Low-grade appendiceal mucinous neoplasms combined with incidental gallbladder cancer: a case report.AME case reports · 2026Article
- Bilateral pulmonary parenchymal metastasis from a low-grade appendiceal mucinous neoplasm.Journal of surgical case reports · 2025Article
- Contract to kill: GNAS mutation.Molecular cancer · 2025Review
- Coexistence of low-grade pulmonary mucinous epithelioid carcinoma and metastatic adrenal sarcomatoid carcinoma: a rare case report with BRAF p.V600E-driven molecular insights and clinical challenges.Frontiers in oncology · 2025Article
- Differentiating appendiceal neoplasm from perforated appendiceal diverticulum in chronic appendicitis: a case report.Journal of surgical case reports · 2024Article
- Case report: A rare case of synchronous mucinous neoplasms of the renal pelvis and the appendix.Frontiers in oncology · 2023Article
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4 authors at 1 institution in 1 country.
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Abstract
Background: Low-grade appendiceal mucinous neoplasms (LAMNs) are indolent tumors with low-grade cytology. Although peritoneal dissemination is common due to tumor rupture and mucinous deposits on the visceral peritoneal surface, distant involvement, such as lung, is rarely seen due to lack of invasiveness. Case Presentation: A 70-year-old woman presented to the hospital due to continuously elevated carcinoembryonic antigen (CEA) levels for 10 months without any symptoms. PET/CT revealed two lesions located in the left lung and appendix. The postoperative pathology results revealed pulmonary mucinous adenocarcinoma and LAMN. Then we performed next-generation sequencing (NGS) to clarify the relationship between the two tumors. The sequencing result showed that both tumors harbored the common tumor mutations, KRAS (p.G12D), GNAS (p.R201H), and BRAF (p.R735Q), which indicated that the pulmonary tumor was a metastasis of LAMN. Conclusion: This case is unusual in that the primary LAMN and the pulmonary metastasis are present at the time of diagnosis. This study reported the first pulmonary metastasis from LAMN verified by NGS.
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