Evidence map›Paper›PMID 35912134›Full record

ArticleBrain communications2022

Utility of the Addenbrooke's Cognitive Examination III online calculator to differentiate the primary progressive aphasia variants.

D Foxe, A Hu, S C Cheung, R M Ahmed, N J Cordato, E Devenney, Y T Hwang, G M Halliday, N Mueller, C E Leyton and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

D FoxeSchool of Psychology, The University of Sydney, 94 Mallett St, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0003-0299-3344
A HuBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
S C CheungSchool of Psychology, The University of Sydney, 94 Mallett St, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0001-5370-7219
R M AhmedBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.ORCID https://orcid.org/0000-0001-6996-8317
N J CordatoBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.ORCID https://orcid.org/0000-0002-4436-0871
E DevenneyBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
Y T HwangBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.ORCID https://orcid.org/0000-0003-4036-3837
G M HallidayBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.ORCID https://orcid.org/0000-0003-0422-8398
N MuellerBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
C E LeytonSchool of Psychology, The University of Sydney, 94 Mallett St, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0002-8236-6561
J R HodgesBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.
J R BurrellBrain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia.ORCID https://orcid.org/0000-0001-9638-2768
M IrishSchool of Psychology, The University of Sydney, 94 Mallett St, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0002-4950-8169
O PiguetSchool of Psychology, The University of Sydney, 94 Mallett St, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0002-6696-1440
The University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Addenbrooke's Cognitive Examination III is a brief cognitive screening tool that is widely used for the detection and monitoring of dementia. Recent findings suggest that the three variants of primary progressive aphasia can be distinguished based on their distinct profiles on the five subdomain scores of this test. Here, we investigated the utility of the Addenbrooke's Cognitive Examination III to differentiate the primary progressive aphasia variants based on their item-by-item performance profiles on this test. From these results, we created an interactive primary progressive aphasia Addenbrooke's Cognitive Examination III calculator which predicts the variant based on a patient's unique item-by-item profile. Twenty-eight logopenic variant, 25 non-fluent variant and 37 semantic variant primary progressive aphasia patients and 104 healthy controls completed the Addenbrooke's Cognitive Examination III at first clinical presentation. Multinomial regression analyses were conducted to establish performance profiles among groups, and R Shiny from RStudio was used to create the interactive Addenbrooke's Cognitive Examination III diagnostic calculator. To verify its accuracy, probability values of the regression model were derived based on a 5-fold cross-validation of cases. The calculator's accuracy was then verified in an independent sample of 17 logopenic, 19 non-fluent and 13 semantic variant primary progressive aphasia patients and 68 Alzheimer's disease patients who had completed the Addenbrooke's Cognitive Examination III (or an older version of this test: Revised) and had

Indexed as

Alzheimer’s diseasecognitive assessmentdata-driven classificationdementia screeningfrontotemporal dementia

Identifiers

PMID35912134
PMCPMC9336588
OpenAlexW4284664529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.