Evidence map›Paper›PMID 35912089›Full record

ArticleFrontiers in aging neuroscience2022

Application of weighted co-expression network analysis and machine learning to identify the pathological mechanism of Alzheimer's disease.

Keping Chai, Xiaolin Zhang, Shufang Chen, Huaqian Gu, Huitao Tang, Panlong Cao, Gangqiang Wang, Weiping Ye, Feng Wan, Jiawei Liang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Keping ChaiDepartment of Pediatrics, Zhejiang Hospital, Hangzhou, China.
Xiaolin ZhangDepartment of Neurological Surgery, Tongji Hospital, Tongji Medical College, Huazhong University Science and Technology, Wuhan, China.
Shufang ChenDepartment of Pediatrics, Zhejiang Hospital, Hangzhou, China.
Huaqian GuDepartment of Pediatrics, Zhejiang Hospital, Hangzhou, China.
Huitao TangDepartment of Pediatrics, Zhejiang Hospital, Hangzhou, China.
Panlong CaoDepartment of Pediatrics, Zhejiang Hospital, Hangzhou, China.
Gangqiang WangDepartment of Pediatrics, Zhejiang Hospital, Hangzhou, China.
Weiping YeDepartment of Pediatrics, Zhejiang Hospital, Hangzhou, China.
Feng WanDepartment of Neurological Surgery, Tongji Hospital, Tongji Medical College, Huazhong University Science and Technology, Wuhan, China.
Jiawei LiangCollege of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Daojiang ShenDepartment of Pediatrics, Zhejiang Hospital, Hangzhou, China.
Zhejiang Hospital · CNTongji Hospital · CNHuazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant deposits of neurofibrillary tangles (NFT), the main characteristic of Alzheimer's disease (AD), are highly related to cognitive impairment. However, the pathological mechanism of NFT formation is still unclear. This study explored differences in gene expression patterns in multiple brain regions [entorhinal, temporal, and frontal cortex (EC, TC, FC)] with distinct Braak stages (0- VI), and identified the hub genes

Indexed as

Braak stagesneurodegenerationrandom forestssGSEAWGCNA

Identifiers

PMID35912089
PMCPMC9326231
OpenAlexW4285086737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.