Evidence map›Paper›PMID 35912080›Full record

ArticleFrontiers in aging neuroscience2022

Age-Related Eye Diseases in Individuals With Mild Cognitive Impairment and Alzheimer's Disease.

Jacqueline Chua, Zheting Zhang, Damon Wong, Bingyao Tan, Bhavani Kulantayan, Chelvin C A Sng, Saima Hilal, Narayanaswamy Venketasubramanian, Boon Yeow Tan, Carol Y Cheung and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
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  4. A deep-learning retinal aging biomarker for cognitive decline and incident dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 5 countries.

Jacqueline ChuaSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Zheting ZhangSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Damon WongSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Bingyao TanSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Bhavani KulantayanSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Chelvin C A SngSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Saima HilalDepartments of Pharmacology and Psychological Medicine, Memory Aging and Cognition Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Narayanaswamy VenketasubramanianDepartments of Pharmacology and Psychological Medicine, Memory Aging and Cognition Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Boon Yeow TanSt. Luke's Hospital, Singapore, Singapore.
Carol Y CheungDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Gerhard GarhöferDepartment of Clinical Pharmacology, Medical University Vienna, Vienna, Austria.
Alina Popa-CherecheanuCarol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Tien Yin WongSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Christopher Li-Hsian ChenDepartments of Pharmacology and Psychological Medicine, Memory Aging and Cognition Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Leopold SchmettererSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Singapore Eye Research Institute · SGNational University of Singapore · SGSingapore National Eye Center · SGChinese University of Hong Kong · CNClinical Emergency Hospital Bucharest · ROMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alzheimer's disease (AD) and age-related eye diseases pose an increasing burden as the world's population ages. However, there is limited understanding on the association of AD/cognitive impairment, no dementia (CIND) with age-related eye diseases. Methods: In this cross-sectional, memory clinic-based study of multiethnic Asians aged 50 and above, participants were diagnosed as AD ( Results: Over half of the adults had at least one eye disease, with AMD being the most common (60.1%; Conclusion: Patients with AD have an increased odds of having moderate DR or worse, which suggests that these vulnerable individuals may benefit from specific social support and screening for eye diseases.

Indexed as

age-related macular degenerationAlzheimer's diseasecognitive impairment no dementiadementiadiabetic retinopathy

Identifiers

PMID35912080
PMCPMC9329945
OpenAlexW4285391043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.