ArticleFrontiers in immunology2022
A causal relationship between leukocyte telomere length and multiple sclerosis: A Mendelian randomization study.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- The Impact of 125I Particle Implantation Therapy on Telomerase Activity and WNT5A/β-catenin Signaling Pathway in Thyroid Cancer Cells.Applied biochemistry and biotechnology · 2026Article
- Suggestive associations between genetically predicted gut microbiota and endometriosis: a two-sample Mendelian randomization study.Journal of medical microbiology · 2026Article
- Telomere length as a marker of biological age in paediatric multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Association between leukocyte telomere length and neurodegenerative diseases: a prospective cohort in the UK Biobank.Journal of neurology · 2026Article
- A Two-way Mendelian randomisation study of inflammatory factors and the risk of meningioma.Translational neuroscience · 2026Article
- Article
- The Relevance of Chronological and Biological Aging in the Progression of Multiple Sclerosis.Healthcare (Basel, Switzerland) · 2025Review
- Association between rheumatoid arthritis and periodontitis: a study based on a two-sample mendelian randomisation analysis.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Association of genetically predicted blood metabolites with osteopenia in individuals over 60 years of age: A Mendelian randomization study.Joint diseases and related surgery · 2025Article
- Causal association between cerebral small vessel disease and epilepsy.Neurosurgical review · 2025Article
- Causal Relationship Between Circulating Metabolites and Sarcopenia-Related Traits: A Mendelian Randomization and Experimental Study.Food science & nutrition · 2025Article
- Causal relationships of serum iron metabolites with sepsis and cardiomyopathy: a Mendelian randomization analysis.Food & nutrition research · 2025Article
- Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS).Immunity & ageing : I & A · 2024Review
- Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis.Neurology. Genetics · 2024Article
- Causal relationship between telomere length and sepsis: a bidirectional Mendelian randomization study.Scientific reports · 2024Article
- Leukocyte telomere length decreased the risk of mortality in patients with alcohol-associated liver disease.Frontiers in endocrinology · 2024Article
- Depression and the risk of fibromyalgia syndrome: a two-sample Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Casual effects of telomere length on sarcoidosis: a bidirectional Mendelian randomization analysis.Frontiers in medicine · 2024Article
- A two-sample bidirectional Mendelian randomization analysis between telomere length and hyperthyroidism.Frontiers in endocrinology · 2024Article
- Reliable Hallmarks and Biomarkers of Senescent Lymphocytes.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Multiple sclerosis (MS) is a chronic inflammatory autoimmune and degenerative disorder of the central nervous system. Telomeres are protective structures located at the ends of linear chromosomes, and leukocyte telomere length (LTL) is closely connected with cell aging and senescence. However, the relationship between LTL and the risk of MS remains unknown. Methods: We performed a two-sample Mendelian randomization (MR) to evaluate whether LTL was causally associated with MS risk. Results: In our MR analysis, 12 LTL-related variants were selected as valid instrumental variables, and a causal relationship between LTL and MS was suggested. The risk of MS nearly doubled as the genetically predicted LTL shortened by one standard deviation (SD) under the inverse variance weighted (IVW) fixed effect model (odds ratio (OR) = 2.00, 95% confidence interval (CI): 1.52-2.62, Conclusions: Our results suggest a potential causal effect of LTL on the risk of MS. Genetically predicted shorter LTL could increase the risk of MS in the European population. LTL should be noted and emphasized in the pathogenesis and treatment of MS.
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Registered trials
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