Evidence map›Paper›PMID 35911729›Full record

ReviewFrontiers in immunology2022

Infiltration Patterns of Cervical Epithelial Microenvironment Cells During Carcinogenesis.

Jianwei Zhang, Silu Meng, Xiuqing Zhang, Kang Shao, Cong Lin

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jianwei ZhangCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Silu MengDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiuqing ZhangCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Kang ShaoBGI-Shenzhen, Shenzhen, China.
Cong LinBGI-Shenzhen, Shenzhen, China.
BGI Group (China) · CNHuazhong University of Science and Technology · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Local cellular microenvironment plays a crucial role in the HPV-induced cervical malignant transformation. Characterization of the dynamic infiltration changes of microenvironment cells during cervical carcinogenesis would contribute to a better understanding of involved mechanisms. Methods: Three public gene expression datasets of cervical squamous epithelium samples were collected and combined. We applied seven up-to-date computational methods for infiltrating estimation and compared their results (CD4 Results: Most methods displayed better performance in predicting the abundance of CD4 Conclusions: Based on characteristics and evaluation performance of different methods, as well as previous findings, for the first time we provide a comprehensive overview of the infiltration patterns of microenvironment cells throughout cervical cancer progression.

Indexed as

CD8-Positive T-LymphocytesUterine Cervical NeoplasmsCarcinogenesisCervix UteriEpithelial CellsFemaleHumansTumor Microenvironmentcervical cancerimmune responseinfiltration patternmicroenvironmentsquamous intraepithelial lesions

Identifiers

PMID35911729
PMCPMC9330475
OpenAlexW4285387578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.