Evidence map›Paper›PMID 35911717›Full record

ArticleFrontiers in immunology2022

The Protective Effect of the Soluble Egg Antigen of

Jie Jiang, Junhui Li, Yu Zhang, Chen Zhou, Chen Guo, Zhaoqin Zhou, Yingzi Ming

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jie JiangCenter for Organ Transplantation, Third Xiangya Hospital, Central South University, Changsha, China.
Junhui LiCenter for Organ Transplantation, Third Xiangya Hospital, Central South University, Changsha, China.
Yu ZhangCenter for Organ Transplantation, Third Xiangya Hospital, Central South University, Changsha, China.
Chen ZhouCenter for Organ Transplantation, Third Xiangya Hospital, Central South University, Changsha, China.
Chen GuoCenter for Organ Transplantation, Third Xiangya Hospital, Central South University, Changsha, China.
Zhaoqin ZhouCenter for Organ Transplantation, Third Xiangya Hospital, Central South University, Changsha, China.
Yingzi MingCenter for Organ Transplantation, Third Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Organ transplantation is currently an effective method for treating organ failure. Long-term use of immunosuppressive drugs has huge side effects, which severely restricts the long-term survival of patients. Materials and methods: Each mouse was intraperitoneally injected with 100 μg of SEA three times a week for four consecutive weeks before allogenic skin transplant. Skin transplants were performed on day 0 to observe graft survival. Pathological examination of skin grafts was conducted 7 days post transplantation. The skin grafts were subjected to mRNA sequencing. Bioinformatics analysis was conducted and the expression of hub genes was verified by qPCR. Flow cytometry analysis was performed to evaluate the immune status and validate the results from bioinformatic analysis. Results: The mean survival time (MST) of mouse skin grafts in the SEA-treated group was 11.67 ± 0.69 days, while that of the control group was 8.00 ± 0.36 days. Pathological analysis showed that Conclusion:

Indexed as

Antigens, HelminthSchistosoma japonicumAnimalsHelminth ProteinsImmunosuppression TherapyInterferon-gammaMiceSkin TransplantationAntigens, Helminthgp50 protein, SchistosomaHelminth ProteinsInterferon-gammacytokine–cytokine receptor interactiongene expressionSchistosoma japonicumskin graftsoluble egg antigen

Identifiers

PMID35911717
PMCPMC9332893
OpenAlexW4285390224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.