Evidence map›Paper›PMID 35911686›Full record

ArticleFrontiers in immunology2022

Evolutionarily Ancient Caspase-9 Sensitizes Immune Effector Coelomocytes to Cadmium-Induced Cell Death in the Sea Cucumber,

Xiaomin Li, Ting Chen, Xiaofen Wu, Zhuobo Li, Xin Zhang, Xiao Jiang, Peng Luo, Chaoqun Hu, Nai-Kei Wong, Chunhua Ren

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Xiaomin LiCAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou, China.
Ting ChenCAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou, China.
Xiaofen WuInstitute for Integrative Biology of the Cell, University of Paris-Saclay, Paris, France.
Zhuobo LiCAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou, China.
Xin ZhangCAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou, China.
Xiao JiangCAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou, China.
Peng LuoCAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou, China.
Chaoqun HuCAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou, China.
Nai-Kei WongClinical Pharmacology Section, Department of Pharmacology, Shantou University of Medical College, Shantou, China.
Chunhua RenCAS Key Laboratory of Tropical Marine Bio-resources and Ecology (LMB), South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou, China.
Chinese Academy of Sciences · CNInstitute of Oceanology · CNSouthern Marine Science and Engineering Guangdong Laboratory (Guangzhou) · CNInstitut de Biologie Intégrative de la Cellule · FRShantou University Medical College · CNSouth China Sea Institute Of Oceanology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heavy-metal pollution has increasingly jeopardized the habitats of marine organisms including the sea cucumber, a seafloor scavenger vital to seawater bio-decontamination, ocean de-acidification and coral-reef protection. Normal physiology including immune functions of sea cucumbers is toxicologically modulated by marine metal pollutants such as cadmium (Cd). The processes underpinning Cd's toxic effects on immune systems in the sea cucumber,

Indexed as

ApoptosisCadmiumCaspase 9HolothuriaAnimalsEnvironmental PollutantsHEK293 CellsHumansHydrogen PeroxideRNA, MessengerSea CucumbersCadmiumCaspase 9Environmental PollutantsHydrogen PeroxideRNA, Messengercadmiumcaspase-9Holothuria leucospilotainvertebrate cell deathreactive oxygen/nitrogen species (ROS/RNS)

Identifiers

PMID35911686
PMCPMC9330033
OpenAlexW4285387180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.