Evidence map›Paper›PMID 35911675›Full record

ArticleFrontiers in immunology2022

Cold Plasma Irradiation Attenuates Atopic Dermatitis

Tao Sun, Xinru Zhang, Chao Hou, Shujun Yu, Yujing Zhang, Zhuo Yu, Ling Kong, Changqing Liu, Lijie Feng, Dong Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. European S2k Guideline on Chronic PruritusActa dermato-venereologica · 2025
    Guideline
  3. Review
  4. Article
  5. Targeting proteostasis pathways for cancer therapy.Journal of pharmaceutical analysis · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Tao SunHefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Xinru ZhangSchool of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Chao HouSchool of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Shujun YuDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yujing ZhangSchool of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Zhuo YuSchool of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Ling KongHefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Changqing LiuHefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Lijie FengSchool of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Dong WangSchool of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Guohua NiHefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Anhui Medical University · CNChinese Academy of Sciences · CNHefei Institutes of Physical Science · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold atmospheric plasma has been widely applied in medical treatment clinically, especially skin diseases. However, the mechanism of cold atmospheric plasma on the treatment of skin diseases is still undefined. In this study, dinitrofluorobenzene-induced atopic dermatitis mice model was constructed. Cold atmospheric plasma was able to decrease skin cells apoptosis, relieve skin inflammation, ER stress and oxidative stress caused by dinitrofluorobenzene stimulation, which was mediated by cold atmospheric plasma-induced MANF expression. In terms of mechanism, hypoxia-inducible factor-1α expression was increased intracellularly after cold atmospheric plasma treatment, which further bound to the promoter region of

Indexed as

Dermatitis, AtopicPlasma GasesAnimalsDinitrofluorobenzeneEndoplasmic Reticulum StressHypoxia-Inducible Factor 1, alpha SubunitMiceNerve Growth FactorsDinitrofluorobenzeneHypoxia-Inducible Factor 1, alpha SubunitMANF protein, mouseNerve Growth FactorsPlasma Gasesatopic dermatitiscold atmospheric plasmahypoxia-inducible factor-1αmesencephalic astrocyte-derived neurotrophic factornuclear factor kappa-B

Identifiers

PMID35911675
PMCPMC9329666
OpenAlexW4285389987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.