Evidence map›Paper›PMID 35911647›Full record

ArticleIranian journal of basic medical sciences2022

Effects of CYP2C19 variants on the metabolism of tapentadol

Ren-Ai Xu, Ping Fang, Zhize Ye, Mingming Han, Jian-Ping Cai, Guo-Xin Hu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ren-Ai XuThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Ping FangThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhize YeSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Mingming HanSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jian-Ping CaiThe Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing.
Guo-Xin HuSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wenzhou Medical University · CNFirst Affiliated Hospital of Wenzhou Medical University · CNFirst Affiliated Hospital Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aims to evaluate the catalytic activities of 31 CYP2C19 alleles and their effects on the metabolism of tapentadol Materials and Methods: Insect microsomes expressing the CYP2C19 alleles were incubated with 50-1250 μM tapentadol for 40 min at 37 °C and terminated by cooling to -80 °C, immediately. Tapentadol and N-desmethyl tapentadol were analyzed by a UPLC-MS/MS system. The kinetic parameters Km, Vmax, and intrinsic clearance (Vmax/Km) of N-desmethyl tapentadol were determined. Results: As a result, the intrinsic clearance (V Conclusion: As the first study of all aforementioned alleles for tapentadol metabolism, the comprehensive data

Indexed as

CYP2C19 variantsCytochrome P450Drug metabolismGenetic polymorphismTapentadol

Identifiers

PMID35911647
PMCPMC9282738
OpenAlexW4289456767

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.