Evidence map›Paper›PMID 35911597›Full record

ReviewFrontiers in human neuroscience2022

Iron and Alzheimer's Disease: From Pathology to Imaging.

Dean Tran, Phillip DiGiacomo, Donald E Born, Marios Georgiadis, Michael Zeineh

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Dean TranDepartment of Radiology, Stanford School of Medicine, Stanford, CA, United States.
Phillip DiGiacomoDepartment of Radiology, Stanford School of Medicine, Stanford, CA, United States.
Donald E BornDepartment of Pathology, Stanford School of Medicine, Stanford, CA, United States.
Marios GeorgiadisDepartment of Radiology, Stanford School of Medicine, Stanford, CA, United States.
Michael ZeinehDepartment of Radiology, Stanford School of Medicine, Stanford, CA, United States.
Stanford Medicine · US

Funding

Iron as an Imaging Biomarker for Inflammation in ADR01AG061120 · NIA · STANFORD UNIVERSITY · PI ZEINEH, MICHAEL M · 2019 to 2023
$3.5M
NOVEL EXOSOME BIOMARKERS OF IRON PATHOLOGY IN ADR21AG072675 · NIA · STANFORD UNIVERSITY · PI DEMIRCI, UTKAN, ZEINEH, MICHAEL M · 2021 to 2021
$433k
NIA NIH HHS R01 AG061120NIA NIH HHS R21 AG072675
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a debilitating brain disorder that afflicts millions worldwide with no effective treatment. Currently, AD progression has primarily been characterized by abnormal accumulations of β-amyloid within plaques and phosphorylated tau within neurofibrillary tangles, giving rise to neurodegeneration due to synaptic and neuronal loss. While β-amyloid and tau deposition are required for clinical diagnosis of AD, presence of such abnormalities does not tell the complete story, and the actual mechanisms behind neurodegeneration in AD progression are still not well understood. Support for abnormal iron accumulation playing a role in AD pathogenesis includes its presence in the early stages of the disease, its interactions with β-amyloid and tau, and the important role it plays in AD related inflammation. In this review, we present the existing evidence of pathological iron accumulation in the human AD brain, as well as discuss the imaging tools and peripheral measures available to characterize iron accumulation and dysregulation in AD, which may help in developing iron-based biomarkers or therapeutic targets for the disease.

Indexed as

Alzheimer’s diseaseiron imagingiron imaging methodsiron mechanismiron microscopy methodsiron MRIiron pathologyiron X-ray methods

Identifiers

PMID35911597
PMCPMC9327617
OpenAlexW4285083522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.