Evidence map›Paper›PMID 35911240›Full record

ArticleFrontiers in psychiatry2022

Is Brain-Derived Neurotropic Factor Methylation Involved in the Association Between Prenatal Stress and Maternal Postnatal Anxiety During the COVID-19 Pandemic?

Livio Provenzi, Marco Villa, Fabiana Mambretti, Andrea Citterio, Serena Grumi, Emanuela Bertazzoli, Giacomo Biasucci, Lidia Decembrino, Barbara Gardella, Roberta Giacchero and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. The role of epigenetics in anxiety disorders.Molecular biology reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Livio ProvenziDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Marco VillaScientific Institute IRCCS E. Medea, Bosisio Parini, Italy.
Fabiana MambrettiScientific Institute IRCCS E. Medea, Bosisio Parini, Italy.
Andrea CitterioScientific Institute IRCCS E. Medea, Bosisio Parini, Italy.
Serena GrumiChild Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia, Italy.
Emanuela BertazzoliASST Lodi, Lodi, Italy.
Giacomo BiasucciGuglielmo da Saliceto Hospital, Piacenza, Italy.
Lidia DecembrinoASST Pavia, Pavia, Italy.
Barbara GardellaDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Roberta GiaccheroASST Lodi, Lodi, Italy.
Maria Luisa MagnaniASST Pavia, Pavia, Italy.
Renata NacinovichASST Monza, Monza, Italy.
Camilla PisoniFondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Federico PrefumoASST Spedali Civili, Brescia, Italy.
Simona OrcesiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Barbara ScelsaASST Sacco Fatebenefratelli, Milan, Italy.
Roberto GiordaScientific Institute IRCCS E. Medea, Bosisio Parini, Italy.
Renato BorgattiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
IRCCS Eugenio Medea · ITUniversity of Pavia · ITAzienda di Servizi alla Persona di Pavia (Italy) · ITAziende Socio Sanitarie Territoriale LodiASST Fatebenefratelli Sacco · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITGuglielmo da Saliceto Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The COVID-19 pandemic is a collective trauma that may expose susceptible individuals to high levels of stress. Pregnant women represent a high-risk population, considering that pregnancy is a period of heightened neuroplasticity and susceptibility to stress through epigenetic mechanisms. Previous studies showed that the methylation status of the Methods: In the present study, we report data on the association among pandemic-related stress during pregnancy, maternal Results: Results showed that pandemic-related stress was associated with an increased risk of postnatal anxiety, Conclusion: These findings suggest that BDNF epigenetic regulation by pandemic-related stress might contribute to increase the risk of anxiety in mothers. Policymakers should prioritize the promotion of health and wellbeing in pregnant women and mothers during the present healthcare emergency.

Indexed as

anxietyBDNFCOVID-19epigeneticsmethylationpandemicpregnancystress

Identifiers

PMID35911240
PMCPMC9329563
OpenAlexW4285391451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.