Evidence map›Paper›PMID 35911151›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2022

Antibiofilm Synergistic Activity of Streptomycin in Combination with Thymol-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles against

Borel Ndezo Bisso, Christian Ramsès Tokam Kuaté, Nathalie Boulens, Eric Allémann, Florence Delie, Jean Paul Dzoyem

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Thymol and carvacrol againstFrontiers in pharmacology · 2024
    Pooled it
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  6. Efficacy of Chlorogenic Acid Combined With Cefazolin Against Methicillin-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Borel Ndezo BissoDepartment of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.ORCID https://orcid.org/0000-0001-5946-9581
Christian Ramsès Tokam KuatéDepartment of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.ORCID https://orcid.org/0000-0002-4667-9835
Nathalie BoulensSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Eric AllémannSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-6598-9521
Florence DelieSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-2637-5949
Jean Paul DzoyemDepartment of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.ORCID https://orcid.org/0000-0003-3568-6711
Université de Dschang · CMUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Thymol is an important component of essential oils found in the oil of thyme, is extracted mainly from Methods: The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The antibiofilm activities were determined by the safranin dye assay. The synergistic effect of Thy-NPs with streptomycin was assessed by the checkerboard method. The kinetic study of the biofilm biomass and time-kill assay were further performed. Results: Thy-NPs exhibited the highest antibacterial activity against Conclusions: Our results indicate that the synergistic bactericidal effect between streptomycin and Thy-NPs could be a promising approach in the control of biofilm-associated infections caused by

Identifiers

PMID35911151
PMCPMC9334066
OpenAlexW4286494090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.