Evidence map›Paper›PMID 35910846›Full record

ArticleOxidative medicine and cellular longevity2022

Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.

Lu Bai, Jing Dai, Yuxuan Xia, Kaichuan He, Hongmei Xue, Qi Guo, Danyang Tian, Lin Xiao, Xiangjian Zhang, Xu Teng and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. cGAS-STING signaling in pollution-induced toxicity: mechanism and relieving medication.Apoptosis : an international journal on programmed cell death · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Lu BaiDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0001-6618-9537
Jing DaiDepartment of Clinical Diagnostics, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0001-5310-6042
Yuxuan XiaDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0002-8304-6930
Kaichuan HeDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0002-0879-9377
Hongmei XueDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0002-9571-0843
Qi GuoDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0001-6762-2929
Danyang TianDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0002-4553-0115
Lin XiaoDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0002-2876-0007
Xiangjian ZhangHebei Collaborative Innovation Center for Cardio-Cerebrovascular Disease, 050017 Hebei, China.ORCID https://orcid.org/0000-0003-0114-1668
Xu TengDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0003-2206-8308
Yuming WuDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0002-3282-056X
Sheng JinDepartment of Physiology, Hebei Medical University, Hebei 050017, China.ORCID https://orcid.org/0000-0001-7777-9700
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although it is an essential nutrient, high choline intake directly or indirectly via its metabolite is associated with increased risk of cardiovascular disease, the mechanism of which remains to be elucidated. The present study was performed to investigate whether hydrogen sulfide (H

Indexed as

Heart DiseasesHydrogen SulfideAnimalsCaspase 1CholineCystathionine gamma-LyaseInflammasomesMembrane ProteinsMiceMice, KnockoutNLR Family, Pyrin Domain-Containing 3 ProteinNLR ProteinsNucleotidyltransferasesSTING ProteinCaspase 1CholineCystathionine gamma-LyaseHydrogen SulfideInflammasomesMembrane ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseNLR ProteinsNucleotidyltransferasesSting1 protein, mouseSTING Protein

Identifiers

PMID35910846
PMCPMC9337966
OpenAlexW4286615437

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.