Evidence map›Paper›PMID 35910604›Full record

ArticleFrontiers in microbiology2022

Discovery of Novel Tyrosinase Inhibitors From Marine Cyanobacteria.

Yifan He, Takashi L Suyama, Hyunwoo Kim, Evgenia Glukhov, William H Gerwick

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Semi-automated, high-content imaging of drug transporter knockout sea urchin (Lytechinus pictus) embryos.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024
    Article
  4. Anti-Melanogenic Effects ofMarine drugs · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Yifan HeScripps Institution of Oceanography, University of California San Diego, La Jolla, CA, United States.
Takashi L SuyamaDepartment of Chemistry and Forensic Science, Waynesburg University, Waynesburg, PA, United States.
Hyunwoo KimScripps Institution of Oceanography, University of California San Diego, La Jolla, CA, United States.
Evgenia GlukhovScripps Institution of Oceanography, University of California San Diego, La Jolla, CA, United States.
William H GerwickScripps Institution of Oceanography, University of California San Diego, La Jolla, CA, United States.
Scripps Institution of Oceanography · USUniversity of California, San Diego · USWaynesburg University · US

Funding

Unified Computation Tools for Natural Products ResearchR01GM107550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COTTRELL, GARRISON W, GERWICK, WILLIAM HENRY · 2013 to 2025
$8.2M
NIGMS NIH HHS R01 GM107550
6 · The paper itself

Abstract

Tyrosinase, an important oxidase involved in the primary immune response in humans, can sometimes become problematic as it can catalyze undesirable oxidation reactions. Therefore, for decades there has been a strong pharmaceutical interest in the discovery of novel inhibitors of this enzyme. Recent studies have also indicated that tyrosinase inhibitors can potentially be used in the treatment of melanoma cancer. Over the years, many new tyrosinase inhibitors have been discovered from various natural sources; however, marine natural products (MNPs) have contributed only a small number of promising candidates. Therefore, in this study we focused on the discovery of new MNP tyrosinase inhibitors of marine cyanobacterial and algal origins. A colorimetric tyrosinase inhibitory assay was used to screen over 4,500 marine extracts against mushroom tyrosinase (

Indexed as

kinetic studymarine cyanobacteria and algaemolecular dockingmushroom tyrosinase inhibitionscytoneminscytonemin monomer synthesisskin whiteningsynergistic effect

Identifiers

PMID35910604
PMCPMC9329053
OpenAlexW4285391908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.