Evidence map›Paper›PMID 35910535›Full record

ArticleStem cells international2022

The Choice of Anticoagulant Influences the Characteristics of Bone Marrow Aspirate Concentrate and Mesenchymal Stem Cell Bioactivity In Vitro.

Ryan C Dregalla, Jessica Ann Herrera, Lucanus Steven Koldewyn, Edward Jeffery Donner

Open access · goldAbstract read
In one paragraph

Article in Stem cells international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ryan C DregallaElite Regenerative Stem Cell Specialists, LLC, 4795 Larimer Parkway, Johnstown, CO 80534, USA.ORCID https://orcid.org/0000-0002-7516-4849
Jessica Ann HerreraElite Regenerative Stem Cell Specialists, LLC, 4795 Larimer Parkway, Johnstown, CO 80534, USA.ORCID https://orcid.org/0000-0001-7091-296X
Lucanus Steven KoldewynElite Regenerative Stem Cell Specialists, LLC, 4795 Larimer Parkway, Johnstown, CO 80534, USA.ORCID https://orcid.org/0000-0003-3139-4164
Edward Jeffery DonnerElite Regenerative Stem Cell Specialists, LLC, 4795 Larimer Parkway, Johnstown, CO 80534, USA.ORCID https://orcid.org/0000-0002-9872-8758
The Spine Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone marrow aspirate concentrate (BMC) is commonly used as a therapeutic agent to resolve orthopedic injuries, using its unique cellularity to reduce inflammation and prime the region for repair. The aspiration of the bone marrow is performed using either sodium citrate (SC) or heparin sodium (HS) as an anticoagulant and processed via centrifugation to concentrate the cellular constituents. To date, the consideration of the impact of the two commonly used anticoagulants on the mesenchymal stem/stromal cell (MSC) population has been overlooked. The current study assesses the differences in the BMCs produced using 15% SC and HS at 1,000 U/mL or 100 U/mL final

Identifiers

PMID35910535
PMCPMC9337942
OpenAlexW4286587576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.