Evidence map›Paper›PMID 35910348›Full record

ArticleFrontiers in pharmacology2022

P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles.

Robin M H Rumney, Justyna Róg, Natalia Chira, Alexander P Kao, Rasha Al-Khalidi, Dariusz C Górecki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Animal Models for the Investigation of P2X7 Receptors.International journal of molecular sciences · 2023
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Robin M H RumneySchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.
Justyna RógDepartment of Biochemistry, Laboratory of Cellular Metabolism, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Natalia ChiraSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.
Alexander P KaoZeiss Global Centre, School of Mechanical and Design Engineering, University of Portsmouth, Portsmouth, United Kingdom.
Rasha Al-KhalidiSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.
Dariusz C GóreckiSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.
University of Portsmouth · GBInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PLWojskowy Instytut Higieny i Epidemiologii · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral deposition and inflammation. One potential link is the P2X7 purinoceptor, a key trigger of inflammation, which is expressed on macrophages but also up-regulated in dystrophic muscle cells. To investigate the role of P2X7 in dystrophic calcification, we utilised the

Indexed as

ectopic calcificationknockinknockoutmacrophageP2X7P2X7 purinoceptor protects against ectopic calcification of dystrophic muscles duchenne muscular dystrophy

Identifiers

PMID35910348
PMCPMC9333129
OpenAlexW4285386821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.