Evidence map›Paper›PMID 35910251›Full record

ArticleFrontiers in cellular neuroscience2022

Chemogenetic Silencing of Differentiating Cortical Neurons Impairs Dendritic and Axonal Growth.

Ina Gasterstädt, Max Schröder, Lukas Cronin, Julian Kusch, Lisa-Marie Rennau, Brix Mücher, Stefan Herlitze, Alexander Jack, Petra Wahle

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ina GasterstädtDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Max SchröderDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Lukas CroninDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Julian KuschDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Lisa-Marie RennauDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Brix MücherDepartment of General Zoology and Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Stefan HerlitzeDepartment of General Zoology and Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Alexander JackDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Petra WahleDevelopmental Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany.
Ruhr University Bochum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrical activity is considered a key driver for the neurochemical and morphological maturation of neurons and the formation of neuronal networks. Designer receptors exclusively activated by designer drugs (DREADDs) are tools for controlling neuronal activity at the single cell level by triggering specific G protein signaling. Our objective was to investigate if prolonged silencing of differentiating cortical neurons can influence dendritic and axonal maturation. The DREADD hM4Di couples to G

Indexed as

dendritogenesishM4Dimetabotropicneurite growthpostnatal developmentpyramidal cell

Identifiers

PMID35910251
PMCPMC9336219
OpenAlexW4285491079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.