Evidence map›Paper›PMID 35910223›Full record

ArticleFrontiers in genetics2022

BNEMDI: A Novel MicroRNA-Drug Interaction Prediction Model Based on Multi-Source Information With a Large-Scale Biological Network.

Yong-Jian Guan, Chang-Qing Yu, Li-Ping Li, Zhu-Hong You, Zhong-Hao Ren, Jie Pan, Yue-Chao Li

Abstract read
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yong-Jian GuanSchool of Information Engineering, Xijing University, Xi'an, China.
Chang-Qing YuSchool of Information Engineering, Xijing University, Xi'an, China.
Li-Ping LiSchool of Information Engineering, Xijing University, Xi'an, China.
Zhu-Hong YouSchool of Computer Science, Northwestern Polytechnical University, Xi'an, China.
Zhong-Hao RenSchool of Information Engineering, Xijing University, Xi'an, China.
Jie PanKey Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Yue-Chao LiSchool of Information Engineering, Xijing University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a novel target in pharmacy, microRNA (miRNA) can regulate gene expression under specific disease conditions to produce specific proteins. To date, many researchers leveraged miRNA to reveal drug efficacy and pathogenesis at the molecular level. As we all know that conventional wet experiments suffer from many problems, including time-consuming, labor-intensity, and high cost. Thus, there is an urgent need to develop a novel computational model to facilitate the identification of miRNA-drug interactions (MDIs). In this work, we propose a novel bipartite network embedding-based method called BNEMDI to predict MDIs. First, the Bipartite Network Embedding (BiNE) algorithm is employed to learn the topological features from the network. Then, the inherent attributes of drugs and miRNAs are expressed as attribute features by MACCS fingerprints and

Indexed as

BiNEdeep neural networkk-merMACCS fingerprintmiRNA–drug interaction

Identifiers

PMID35910223
PMCPMC9334674

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.