ArticleThe Pan African medical journal2022
Oxidative stress is associated with markers of renal dysfunction in children aged 6-9 years old in a South African population.
Article in The Pan African medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 1 citations in OpenAlex.
- The toxic footprint of lead exposure: oxido-inflammatory biomarkers in urban populations of Niger Delta, Nigeria.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Association of Oxidative Stress Markers with Cardio-Kidney-Metabolic Parameters and Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus.Biomolecules · 2025Article
- Correlation of Oxidative Stress Biomarkers with Activity of Pediatric Idiopathic Nephrotic Syndrome.Biomedicines · 2025Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Introduction: although studies have shown a relationship between albuminuria and oxidative stress in adults, limited information on the subject is available in children. The aim of this study was to assess the relationship between oxidative stress and albuminuria in South African children of African ancestry. Methods: a cross-sectional study involving 6-9 years old children in randomly selected rural and urban schools of the Eastern Cape Province of South Africa was conducted. Anthropometric measurements were done and urine samples were collected for the determination of titres of albumin, creatinine, 8-hydroxy-2-deoxy-guanosine (8-OHdG) and thiobarbituric acid reactive substances (TBARS). The urinary albumin to creatinine ratio (ACR) was calculated and used to determine albuminuria. Results: creatinine and 8-OHdG were significantly higher (p<0.05) in urban children than in rural children while albumin, ACR and TBARS were significantly higher (p<0.05) in rural compared to urban children. The prevalence of albuminuria was 14.05% of which microalbuminuria was 8.83% while macroalbuminuria was 5.22%. Albuminuria was higher in rural children than their urban counterparts and was more prevalent in females. TBARS was positively (p<0.05) associated with creatinine and albumin in the cohort as well as in females and urban children while 8-OHdG was positively associated with albumin in the cohort. Conclusion: findings of this study showed that oxidative stress was associated with markers of renal dysfunction with a 14% prevalence of albuminuria observed in South African children of African ancestry.
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