Evidence map›Paper›PMID 35909944›Full record

ArticleOncoimmunology2022

Enriched circulating and tumor-resident TGF-β

Robert J Harris, Zena Willsmore, Roman Laddach, Silvia Crescioli, Jitesh Chauhan, Anthony Cheung, Anna Black, Jenny L C Geh, Alastair D MacKenzie Ross, Ciaran Healy and 4 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Review
  3. B cells in cancer: functions, mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Regulatory B Cells in Tumor Microenvironment.Current issues in molecular biology · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Robert J HarrisSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Zena WillsmoreSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Roman LaddachSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Silvia CrescioliSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Jitesh ChauhanSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Anthony CheungSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Anna BlackSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Jenny L C GehDepartment of Plastic Surgery at Guy's, King's, and St. Thomas' NHS Foundation Trust, London, UK.
Alastair D MacKenzie RossDepartment of Plastic Surgery at Guy's, King's, and St. Thomas' NHS Foundation Trust, London, UK.
Ciaran HealyDepartment of Plastic Surgery at Guy's, King's, and St. Thomas' NHS Foundation Trust, London, UK.
Sophia TsokaDepartment of Informatics, Faculty of Natural, Mathematical and Engineering Sciences, King's College London, London, UK.
James SpicerSchool of Cancer & Pharmaceutical Sciences, King's College London, Guy's Hospital, London, UK.
Katie E LacySt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
Sophia N KaragiannisSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.ORCID 0000-0002-4100-7810
Guy's Hospital · GBGuy's and St Thomas' NHS Foundation Trust · GBKing's College London · GB

Funding

Cancer Research UK C10355/A15587Cancer Research UK C30122/A11527Cancer Research UK C30122/A15774Cancer Research UK C604/A25135Department of Health IS-BRC-1215-20006Medical Research Council MR/L023091/1
6 · The paper itself

Abstract

B cells are emerging as key players of anti-tumor adaptive immune responses. We investigated regulatory and pro-inflammatory cytokine-expressing B cells in patients with melanoma by flow cytometric intracellular cytokine, CyTOF, transcriptomic, immunofluorescence, single-cell RNA-seq, and B:T cell co-culture analyses. We found enhanced circulating regulatory (TGF-β

Indexed as

B-Lymphocytes, RegulatoryMelanomaSkin NeoplasmsT-Lymphocytes, RegulatoryForkhead Transcription FactorsHumansTransforming Growth Factor betaTumor MicroenvironmentTumor Necrosis Factor-alphaForkhead Transcription FactorsFOXP3 protein, humanTransforming Growth Factor betaTumor Necrosis Factor-alphaB cellimmune checkpointinflammatory B cellMelanomaregulatory B cellregulatory T cellTGF-βTNF-αTumor-infiltrating lymphocytestumor microenvironment

Identifiers

PMID35909944
PMCPMC9336482
OpenAlexW4288096597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.