Evidence map›Paper›PMID 35909891›Full record

ArticleDisease markers2022

Transient Receptor Potential Vanilloid-1 (TRPV1) Alleviates Hepatic Fibrosis via TGF-

Ke Qian, Xiaohua Lei, Guoxing Liu, Yu Fang, Chengzhi Xie, Xiaolong Wu, Qiang Liu, Gao Liu, Zhenyu Cao, Ju Zhang and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. The Role of Cannabidiol in Liver Disease: A Systemic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Review
  3. Review
  4. Article
  5. Role of TRP Channels in Metabolism-Related Diseases.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 3 countries.

Ke QianDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Xiaohua LeiDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.ORCID https://orcid.org/0000-0003-4028-9841
Guoxing LiuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Yu FangDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Chengzhi XieDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Xiaolong WuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Qiang LiuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Gao LiuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Zhenyu CaoDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Ju ZhangDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Tao KuangDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Likun YanDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Jie FuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Huihui DuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Zhiqiang LiuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Yuan ChuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Ge XuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.
Hirofumi YamamotoDepartment of Molecular Pathology, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.
Masaki MoriDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Xin M LiangWellman Center for Photomedicine, Department of Medicine, Division of Endocrinology, Massachusetts General Hospital, VA Boston Healthcare System, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.
Xundi XuDivision of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, The Second Xiangya Hospital, Central South University, Hunan Provincial Key Laboratory of Hepatobiliary Disease Research, Changsha, Hunan 410011, China.ORCID https://orcid.org/0000-0003-4287-4358
Central South University · CNBeth Israel Deaconess Medical Center · USKyushu University · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic fibrosis is a major global health problem and considered a leading cause of liver-related morbidity and mortality worldwide. Although previous studies have suggested that transient receptor potential vanilloid-1 (TRPV1) is protective against cardiac and renal fibrosis, its functional role in hepatic fibrosis has remained elusive. Herein, we characterize the effects of TRPV1 on carbon tetrachloride- (CCl

Indexed as

LiverLiver CirrhosisTransforming Growth Factor beta1TRPV Cation ChannelsAnimalsCapsaicinFibrosisHepatic Stellate CellsHumansMiceTransforming Growth Factor betaCapsaicinTransforming Growth Factor betaTransforming Growth Factor beta1TRPV1 protein, humanTRPV1 protein, mouseTRPV Cation Channels

Identifiers

PMID35909891
PMCPMC9334033
OpenAlexW4286499672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.