Evidence map›Paper›PMID 35909588›Full record

ArticleContrast media & molecular imaging2022

IGF-1 Promotes Epithelial-Mesenchymal Transition of Lens Epithelial Cells That Is Conferred by miR-3666 Loss.

Chao Wang, Baowen Zhao, Jiahui Fang, Zhan Shi

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Contrast media & molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. PeerJ · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chao WangThe First Affiliated Hospital of Harbin Medical University, Anesthesiolgy Department, Harbin, China.
Baowen ZhaoHongqi Hospital Affiliated to Mudanjiang Medical College, Ophthalmology Department, Mudanjiang, China.
Jiahui FangThe First Affiliated Hospital of Harbin Medical University, Ophthalmology Department, Harbin, China.
Zhan ShiThe First Affiliated Hospital of Harbin Medical University, Ophthalmology Department, Harbin, China.ORCID 0000-0001-8041-5756
Harbin Medical University · CNMudanjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The abnormal proliferation, migration, and epithelial-mesenchymal transformation (EMT) of lens epithelial cells (LECs) are the main reasons for vision loss caused by posterior capsular opacification (PCO) after cataract surgery. Insulin-like growth factor-1 (IGF-1) was found to be associated with the pathogenesis of cataracts, but its biological role in PCO is poorly understood. In the present study, IGF-1 overexpression facilitated the proliferation, migration, and EMT, whereas knockdown of IGF-1 markedly suppressed the proliferation, migration, and TGF-

Indexed as

Capsule OpacificationInsulin-Like Growth Factor ILens, CrystallineMicroRNAsCell MovementCell ProliferationEpithelial CellsEpithelial-Mesenchymal TransitionHumansIGF1 protein, humanInsulin-Like Growth Factor IMicroRNAsMIRN3666 microRNA, human

Identifiers

PMID35909588
PMCPMC9303496
OpenAlexW4285390797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.