Evidence map›Paper›PMID 35909543›Full record

ArticleFrontiers in endocrinology2022

Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?

Xudong Shen, Yang Chen, Yan Chen, Hu Liang, Guoxiang Li, Zongyao Hao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Association of Estimated Glucose Disposal Rate With Prevalent Kidney Stones: A Large-Scale Cross-Sectional Study in China.Medical science monitor : international medical journal of experimental and clinical research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xudong ShenDepartment of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei City, China.
Yang ChenDepartment of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei City, China.
Yan ChenDepartment of General Practice, Wuhu City Second People`s Hospital, Wuhu City, China.
Hu LiangDepartment of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei City, China.
Guoxiang LiDepartment of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei City, China.
Zongyao HaoDepartment of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei City, China.
Anhui Medical University · CNFirst Affiliated Hospital of Anhui Medical University · CNWuhu Fourth People Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The purpose of this study was to examine whether the METS-IR index is associated with kidney stones in American adults. Method: Participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007-2018 were selected for logistic regression analysis, subgroup analyses, and the calculation of dose-response curves to assess the association between the METS-IR index and the incidence of kidney stones. Result: This study enrolled 30,612 adults aged >20 years, 2901 of whom self-reported having had kidney stones in the past. And, after controlling for potential confounders, each unit increase in the METS-IR index was linked with a 1.23 percent rise in kidney stone incidence (OR= 1.0123, 95% CI: 1.0092 - 1.0155), with stratified analysis indicating that this was true in all subgroups. Between all groups, an elevated METS-IR index was related to kidney stone formation, and the dose-response curve revealed a positive non-linear connection between METS-IR index and kidney stone risk, with a threshold effect analysis revealing an inflection point value of 50.8314. Conclusion: Higher METS-IR index is associated with the occurrence of kidney stones,and while no causative association can be shown, this is cause for concern.

Indexed as

Insulin ResistanceKidney CalculiMetabolic SyndromeAdultBiomarkersHumansNutrition SurveysUnited StatesBiomarkersinsulin resistancekidney stonesmetabolic syndromeMETS-IR indexNHENSE (National Health and Nutrition Examination Survey)

Identifiers

PMID35909543
PMCPMC9329808
OpenAlexW4289457279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.