ArticleFrontiers in molecular neuroscience2022
Prognostic values of serum alkaline phosphatase and globulin levels in patients undergoing intravenous thrombolysis.
Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 6 citations in OpenAlex.
- Integrating serum globulin into the ICF framework: a novel multidimensional predictive model for 1-year mRS outcomes in acute ischemic stroke.European journal of medical research · 2026Article
- Impact of alkaline phosphatase on clinical outcomes in patients with ischemic stroke: a nationwide registry analysis.Frontiers in neurology · 2024Article
- Alkaline phosphatase and mortality in stroke patients: a systematic review.Annals of translational medicine · 2023Review
- Article
- Serum alkaline phosphatase levels at admission are associated with unfavorable prognosis in acute ischemic stroke patients undergoing endovascular thrombectomy.Frontiers in neurologyArticle
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9 authors at 2 institutions in 1 country.
Funding
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Abstract
Background: In previous studies, alkaline phosphatase (ALP) level was a prognostic factor for patients with ischemic stroke, and globulin level was associated with hemorrhagic transformation (HT) after intravenous thrombolysis (IVT). However, the association between these serum biomarkers and prognosis in patients with acute ischemic stroke (AIS) who undergo IVT remains unclear. This study aimed to investigate the characteristics of serum ALP and globulin levels after IVT and to assess the relationship between these serum biomarkers and prognosis. Materials and methods: This retrospective study used a prospectively collected database. We included patients with AIS who received recombinant tissue plasminogen activator (rt-PA) IVT. Demographic information, vascular risk factors, laboratory test results, and other stroke-related data were collected for analysis. Clinical outcomes included HT and 3-month poor outcome (modified Rankin Scale scores ≥ 2) after IVT. The association of ALP and globulin levels with HT and poor outcome was investigated using multivariate logistic regression analysis. An individualized prediction model based on ALP and globulin levels for functional outcomes was established. Results: We enrolled 750 patients in this study; 452 patients (60.3%) had poor outcome, and 117 patients (15.6%) had HT after IVT. After adjusting for all confounders, serum globulin level [OR = 1.055; 95% confidence intervals (CI): 1.006-1.107; Conclusion: This study found that higher serum globulin levels were independently associated with HT. Additionally, higher serum ALP and globulin levels were independently associated with a poor outcome in patients after IVT.
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