Evidence map›Paper›PMID 35909441›Full record

ArticleThe Lancet. Rheumatology2022

Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study.

Zara Izadi, Milena A Gianfrancesco, Gabriela Schmajuk, Lindsay Jacobsohn, Patricia Katz, Stephanie Rush, Clairissa Ja, Tiffany Taylor, Kie Shidara, Maria I Danila and 51 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. [The German COVID-19 rheumatism register].Zeitschrift fur Rheumatologie · 2024
    Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

61 authors at 20 institutions in 15 countries.

Zara IzadiDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
Milena A GianfrancescoDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
Gabriela SchmajukDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
Lindsay JacobsohnDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
Patricia KatzDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
Stephanie RushDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
Clairissa JaDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
Tiffany TaylorDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
Kie ShidaraDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
Maria I DanilaDivision of Clinical Immunology and Rheumatology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Katherine D WyshamVA Puget Sound Health Care System and Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA.
Anja StrangfeldGerman Rheumatism Research Center, Epidemiology and Health Care Research, Berlin, Germany.
Elsa F MateusPortuguese League Against Rheumatic Diseases, Lisbon, Portugal.
Kimme L HyrichCentre for Epidemiology Versus Arthritis, University of Manchester, Manchester, UK.
Laure GossecINSERM, Sorbonne Universites, Groupe Hopital Universitaire Pitie Salpetriere, AP-HP, Paris, France.
Loreto CarmonaInstituto de Salud Musculoesquelética, Madrid, Spain.
Saskia Lawson-ToveyCentre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK.
Lianne Kearsley-FleetCentre for Epidemiology Versus Arthritis, University of Manchester, Manchester, UK.
Martin SchaeferGerman Rheumatism Research Center, Epidemiology and Health Care Research, Berlin, Germany.
Samar Al-EmadiHamad Medical Corporation, Doha, Qatar.
Jeffrey A SparksBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Tiffany Y-T HsuDivision of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Naomi J PatelDivision of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Leanna WiseUniversity of Southern California, Los Angeles, CA, USA.
Emily GilbertDivision of Rheumatology, Mayo Clinic, Jacksonville, FL, USA.
Alí Duarte-GarcíaDivision of Rheumatology, Mayo Clinic, Rochester, MN, USA.
Maria O Valenzuela-AlmadaDivision of Rheumatology, Mayo Clinic, Rochester, MN, USA.
Manuel F Ugarte-GilSchool of Medicine, Universidad Científica del Sur, Lima, Peru.
Lotta LjungDepartment of Public Health and Clinical Medicine and Department of Rheumatology, Umeå University, Umeå, Sweden.
Carlo A ScirèEpidemiology Research Unit, Italian Society for Rheumatology, Milan, Italy.
Greta CarraraEpidemiology Research Unit, Italian Society for Rheumatology, Milan, Italy.
Eric HachullaINSERM, CHU Lille, Service de Médecine Interne et Immunologie Clinique, Centre de référence des maladies autoimmunes systémiques rares du Nord et Nord-Ouest de France, U1286-INFINITE-Institute for Translational Research in Inflammation, Université de Lille, Lille, France.
Christophe RichezDepartment of Rheumatology, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Bordeux, France.
Patrice CacoubINSERM 959, Sorbonne Universites, Groupe Hopital Universitaire Pitie Salpetriere, AP-HP, Paris, France.
Thierry ThomasDépartement de Médecine Interne et Immunologie Clinique, Sorbonne Universites, Groupe Hopital Universitaire Pitie Salpetriere, AP-HP, Paris, France.
Maria J SantosRheumatology Department, Hospital Garcia de Orta, Almada, Portugal.
Miguel BernardesDepartment of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal.
Rebecca HasseliDepartment of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Germany.
Anne RegiererGerman Rheumatism Research Center, Epidemiology and Health Care Research, Berlin, Germany.
Hendrik Schulze-KoopsDivision of Rheumatology and Clinical Immunology, Department of Medicine IV, Ludwig-Maximilians-University Munich, Munich, Germany.
Ulf Müller-LadnerDepartment of Rheumatology and Clinical Immunology, Justus-Liebig University Giessen, Germany.
Guillermo Pons-EstelArgentine Society of Rheumatology, Buenos Aires, Argentina.
Romina TantenHospital Francisco Lopez Lima, General Roca, Argentina.
Romina E NietoDepartment of Rheumatology, Grupo Oroño-Centro Regional de Enfermedades Autoinmunes y Reumáticas, Rosario, Santa Fe, Argentina.
Cecilia N PisoniRheumatology and Immunology Section, Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno", Buenos Aires, Argentina.
Yohana S TisseraServicio de Clínica Médica, Unidad de Reumatología del Hospital Córdoba and Sanatorio Parque de Córdoba, Córdoba, Argentina.
Ricardo XavierHospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Claudia D Lopes MarquesHospital das Clínicas, Universidade Federal de Pernambuco, Recife, Brazil.
Gecilmara C S PileggiHospital São Paulo, Universidade Federal de São Paulo, Brazil.
Philip C RobinsonUniversity of Queensland Medical School, Brisbane, QLD, Australia.
Pedro M MachadoUniversity College London, University College London Hospitals NHS Foundation Trust, Northwick Park Hospital, London North-West University Healthcare NHS Trust, London, UK.
Emily SirotichDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Jean W LiewBoston University School of Medicine, Boston, MA, USA.
Jonathan S HausmannBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Paul SufkaHealthPartners, St Paul, MN, USA.
Rebecca GraingerDepartment of Medicine, University of Otago Wellington, Wellington, New Zealand.
Suleman BhanaPfizer, New York, NY, USA.
Monique Gore-MassyAffiliation Lupus Foundation of America, Washington, DC, USA.
Zachary S WallaceDivision of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jinoos YazdanyDivision of Rheumatology, School of Medicine, University of California, San Francisco, CA, USA.
COVID-19 Global Rheumatology Alliance Registry
University of Lisbon · PTUniversity of California, San Francisco · USGerman Rheumatism Research Centre · DECentro de Educación Médica e Investigaciones Clínicas Norberto Quirno · ARHarvard University · USInserm · FRMayo Clinic in Arizona · USBrigham and Women's Hospital · USCentre National de la Recherche Scientifique · FRHospital Provincial de Rosario · ARCanadian Arthritis Patient Alliance · CAJustus-Liebig-Universität Gießen · DELupus Foundation of America · USManchester Academic Health Science Centre · GBPfizer (United States) · USSan Francisco VA Medical Center · USServicio Diabetología Hospital Córdoba · ARSocietà Italiana di Reumatologia · ITThe University of Queensland · AUUniversidad Científica del Sur · PE

Funding

VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
Research Training in Rheumatology at Massachusetts General HospitalT32AR007258 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDREW D LUSTER · 1986 to 2026
$6.9M
Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung DiseaseR01AR077607 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2021 to 2025
$3.7M
Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic DiseasesR01AR080659 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Jeffrey Andrew Sparks · 2023 to 2026
$2.9M
Advancing Quality and Outcomes Measurement in RheumatologyK24AR074534 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jinoos Yazdany · 2019 to 2026
$1.5M
Rheumatoid Arthritis and Respiratory Outcomes in Prospective CohortsK23AR069688 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2016 to 2020
$766k
Respiratory Diseases, Genetics, and Rheumatoid Arthritis RiskR03AR075886 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2019 to 2020
$179k
Examining the causal effect of sociodemographic and genetic factors on patient safety outcomes in individuals prescribed high-risk immunosuppressive medicationsF32AR070585 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIANFRANCESCO, MILENA ANNE · 2017 to 2018
$125k
NIAMS NIH HHS F32 AR070585NIAMS NIH HHS K23 AR069688NIAMS NIH HHS K24 AR074534NIAMS NIH HHS L30 AR066953NIAMS NIH HHS P30 AR070155NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30 AR072577NIAMS NIH HHS R01 AR077607NIAMS NIH HHS R03 AR075886NIAMS NIH HHS T32 AR007258
6 · The paper itself

Abstract

Background: Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally. Methods: In this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death. Findings: 14 044 patients from 23 countries were included in the analyses. 10 178 (72·5%) individuals were female and 3866 (27·5%) were male, with a mean age of 54·4 years (SD 15·6). Air pollution (odds ratio 1·10 per 10 μg/m Interpretation: Our findings highlight the importance of environmental and societal factors as potential explanations of the observed regional disparities in COVID-19 outcomes among people with rheumatic disease and lay foundation for a new research agenda to address these disparities. Funding: American College of Rheumatology and European Alliance of Associations for Rheumatology.

Identifiers

PMID35909441
PMCPMC9313519
OpenAlexW4287734667

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.