Evidence map›Paper›PMID 35909174›Full record

Observational studyCritical care (London, England)2022

Capnodynamic monitoring of lung volume and blood flow in response to increased positive end-expiratory pressure in moderate to severe COVID-19 pneumonia: an observational study.

Luis Schulz, Antony Stewart, William O'Regan, Peter McCanny, Danielle Austin, Magnus Hallback, Mats Wallin, Anders Aneman

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05082168 (Capnodynamic Monitoring of Cardiorespiratory Function in Patients Admitted to the Intensive Care Unit With COVID-19 Infection, Sepsis and Following Cardiac Surgery), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05082168 unknown statusnot on this map

Capnodynamic Monitoring of Cardiorespiratory Function in Patients Admitted to the Intensive Care Unit With COVID-19 Infection, Sepsis and Following Cardiac Surgery

TypeobservationalSponsorSouth West Sydney Local Health DistrictRan2021 to 2023Enrolled100ConditionsAcute Respiratory Infection, Sepsis, Postoperative Respiratory DistressArmsCapnodynamic monitoring
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Luis SchulzIntensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District, Locked Bag 7103, Liverpool BC, NSW, 1871, Australia.
Antony StewartIntensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District, Locked Bag 7103, Liverpool BC, NSW, 1871, Australia.
William O'ReganIntensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District, Locked Bag 7103, Liverpool BC, NSW, 1871, Australia.
Peter McCannyIntensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District, Locked Bag 7103, Liverpool BC, NSW, 1871, Australia.
Danielle AustinIntensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District, Locked Bag 7103, Liverpool BC, NSW, 1871, Australia.
Magnus HallbackMaquet Critical Care AB, Solna, Sweden.
Mats WallinDepartment of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Anders AnemanIntensive Care Unit, Liverpool Hospital, South Western Sydney Local Health District, Locked Bag 7103, Liverpool BC, NSW, 1871, Australia. anders.aneman@health.nsw.gov.au.
Liverpool Hospital · AUSouth Western Sydney Local Health District · AUImmune Therapy Holdings (Sweden) · SEKarolinska Institutet · SEUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe optimal level of positive end-expiratory pressure (PEEP) during mechanical ventilation for COVID-19 pneumonia remains debated and should ideally be guided by responses in both lung volume and perfusion. Capnodynamic monitoring allows both end-expiratory lung volume ([Formula: see text]) and effective pulmonary blood flow (EPBF) to be determined at the bedside with ongoing ventilation.

methodsPatients with COVID-19-related moderate to severe respiratory failure underwent capnodynamic monitoring of [Formula: see text] and EPBF during a step increase in PEEP by 50% above the baseline (PEEP

resultsOf 27 patients studied, 15 responders increased the P/F ratio by 55 [24-86] mm Hg compared to 12 non-responders (p < 0.01) as PEEP

conclusionsIn mechanically ventilated patients with moderate to severe COVID-19 respiratory failure, improved oxygenation in response to increased PEEP was associated with increased end-expiratory lung volume and pulmonary perfusion. The change in end-expiratory lung volume was positively correlated with the lung volume recruited and the recruitment-to-inflation ratio. This study demonstrates the feasibility of capnodynamic monitoring to assess physiological responses to PEEP at the bedside to facilitate an individualised setting of PEEP.

trial registrationNCT05082168 (18th October 2021).

Indexed as

COVID-19Respiratory InsufficiencyHumansLung Volume MeasurementsOxygenPositive-Pressure RespirationTidal VolumeOxygenCOVID-19Lung perfusionLung volumeMechanical ventilationMonitoringPositive end-expiratory pressure

Identifiers

PMID35909174
PMCPMC9340710
OpenAlexW4288967996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.