Evidence map›Paper›PMID 35909169›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2022

Antinociceptive effects of bupivacaine and its sulfobutylether-β-cyclodextrin inclusion complex in orofacial pain.

Juliana Souza de Freitas Domingues, Silmara Martins Dias Dos Santos, Julia das Neves Rodrigues Ferreira, Bianca Miguel Monti, Darciane Favero Baggio, Wagner Hummig, Erika Ivanna Araya, Eneida de Paula, Juliana Geremias Chichorro, Luiz Eduardo Nunes Ferreira

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Juliana Souza de Freitas DominguesLaboratory of Inflammation and Immunology, Guarulhos University, Guarulhos, São Paulo, Brazil.ORCID 0000-0003-2877-9311
Silmara Martins Dias Dos SantosLaboratory of Inflammation and Immunology, Guarulhos University, Guarulhos, São Paulo, Brazil.
Julia das Neves Rodrigues FerreiraLaboratory of Inflammation and Immunology, Guarulhos University, Guarulhos, São Paulo, Brazil.
Bianca Miguel MontiLaboratory of Inflammation and Immunology, Guarulhos University, Guarulhos, São Paulo, Brazil.
Darciane Favero BaggioDepartment of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, Parana, Brazil.ORCID 0000-0001-5915-4774
Wagner HummigDepartment of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, Parana, Brazil.ORCID 0000-0003-1651-6610
Erika Ivanna ArayaDepartment of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, Parana, Brazil.ORCID 0000-0001-7957-2738
Eneida de PaulaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, Sao Paulo, Brazil.ORCID 0000-0003-4504-5723
Juliana Geremias ChichorroDepartment of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, Parana, Brazil.ORCID 0000-0001-5345-141X
Luiz Eduardo Nunes FerreiraLaboratory of Inflammation and Immunology, Guarulhos University, Guarulhos, São Paulo, Brazil. luiz.ferreira@prof.ung.br.ORCID 0000-0002-4882-5402
Guarulhos University · BRUniversidade Federal do Paraná · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bupivacaine hydrochloride (BVC) represents an option to produce long-lasting analgesia, and complexation in cyclodextrins has shown improvements in biopharmaceutical properties. This study aimed to characterize and test the cytotoxicity and antinociceptive effects of BVC complexed in sulfobutylether-β-cyclodextrin (SBEβCD). The kinetics and stoichiometry of complexation and BVC-SBEβCD association constant were evaluated by phase solubility study and Job's plot. Evidence of the BVC-SBEβCD complex formation was obtained from scanning electron microscopy (SEM), infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). The cytotoxicity was evaluated in keratinocyte (HaCaT) and neuroblastoma (SH-SY5Y). Antinociceptive effects were registered via orofacial pain models: the formalin test, carrageenan-induced hyperalgesia, and postoperative pain (intraoral incision). The complex formation occurred at a 1:1 BVC-SBEβCD molar ratio, with a low association constant (13.2 M

Indexed as

Biological ProductsCyclodextrinsNeuroblastomaAnalgesicsbeta-CyclodextrinsBupivacaineCarrageenanFacial PainHumansSolubilityAnalgesicsbeta-CyclodextrinsBiological ProductsBupivacaineCarrageenanCyclodextrinsSBE4-beta-cyclodextrinBupivacaineCytotoxicityDrug deliveryHyperalgesiaOrofacial painSulfobutylether-β-cyclodextrin

Identifiers

PMID35909169
OpenAlexW4289101058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.