Evidence map›Paper›PMID 35908972›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Two Cases of Thymic Cancer in Patients with Lynch Syndrome.

Mototsugu Watanabe, Kohji Tanakaya, Shinichi Furukawa, Toshio Shiotani, Yumiko Sato, Fumitaka Taniguchi, Nobuhiko Kanaya, Hideki Aoki, Koukichi Sugano, Hideyuki Ishida and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Mototsugu WatanabeDepartment of Thoracic Surgery, Iwakuni Clinical Center, Japan.
Kohji TanakayaDepartment of Surgery, Iwakuni Clinical Center, Japan.
Shinichi FurukawaDepartment of Thoracic Surgery, Iwakuni Clinical Center, Japan.
Toshio ShiotaniDepartment of Thoracic Surgery, Iwakuni Clinical Center, Japan.
Yumiko SatoDepartment of Pathology, Iwakuni Clinical Center, Japan.
Fumitaka TaniguchiDepartment of Surgery, Iwakuni Clinical Center, Japan.
Nobuhiko KanayaDepartment of Surgery, Iwakuni Clinical Center, Japan.
Hideki AokiDepartment of Surgery, Iwakuni Clinical Center, Japan.
Koukichi SuganoDepartment of Genetic Medicine, Kyoundo Hospital, Sasaki Foundation, Japan.
Hideyuki IshidaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Japan.
Kiwamu AkagiDivision of Molecular Diagnosis and Cancer Prevention, Saitama Cancer Center, Japan.
Kazuhiko KataokaDepartment of Thoracic Surgery, Iwakuni Clinical Center, Japan.
Iwakuni Medical Center · JPSaitama Cancer Center · JPSaitama Medical University · JPSasaki Institute · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report two cases of thymic cancer with Lynch syndrome showing a high frequency of microsatellite instability and loss of mismatch repair protein expression without MLH1 promoter hyper-methylation. In Case 1, a 71-year-old man had a pathogenic germline variant in MLH1 and underwent tumor resection. No relapse has been reported thus far. In Case 2, a 43-year-old man underwent genetic testing that also showed a pathogenic germline variant in MLH1. Since these two cases had MLH variants, we suspect a possible association between thymic cancer with Lynch syndrome and germline pathogenic variants in MLH1.

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisThymus NeoplasmsAdultAgedDNA MethylationGerm-Line MutationHumansMaleMutL Protein Homolog 1Neoplasm Recurrence, LocalMutL Protein Homolog 1high frequency of microsatellite instability (MSI-H)Lynch syndromethymic cancer

Identifiers

PMID35908972
PMCPMC10017246
OpenAlexW4288474517

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.